About

HC Hemker Prof. H.C. Hemker (1934) obtained an MD and PhD from the University of Amsterdam. After a training in paediatrics and chemical pathology he became principle investigator in charge of Haemostasis and Thrombosis research at the University of Leiden (1962) and remained in that field since then.

He became professor of internal medicine in Leiden in 1968 and, part time, at the free university of Brussels in 1972. In 1973 he was asked by the Dutch government to be responsible for basic sciences among the seven people that prepared the new medical faculty at Maastricht. In 1975 he became chairman of the department of Biochemistry there. From 1982-1985 he was rector magnificus of that university. He is a member of the Royal Dutch Academy of Arts and Sciences since 1986.

Hemker has been visiting professor at the medical faculty of Paris (V and VI) and the “Collège de France” and affiliated professor at Mount Sinai Medical School (NY, USA).

Hemker is (co-)author of over 500 scientific articles in his domain of research and of several books. He received several prizes and awards as well as French and Dutch distinctions. Over 400 selected scientific articles of Prof. Hemker are published on this website.

Since his retirement from his university chair (1999) he became head of a research group within the CArdiovascular Research Institute Maastricht (CARIM) and director of Synapse BV, a scientific consultation and development company.

Curriculum Vitae - Hendrik Coenraad Hemker
Born on July 21, 1934 in Amsterdam, the Netherlands

Main present positions

  • Emeritus Professor and Senior Councillor Cardiovascular Research Institute Maastricht (CARIM)
  • Director of Synapse BV, Research, Development and Consultation in Haemostasis and Thrombosis.

Career

  • MD University of Amsterdam 1959
  • PhD in Biochemistry, University of Amsterdam 1962 (Prof. Dr. E.C. Slater).
  • Head of the research laboratory of the Division of Haemostasis and Thrombosis, Department of Internal Medicine, University of Leiden, 1962-1968.
  • Professor of Internal Medicine, for the biochemistry of heart- and vessel diseases, University of Leiden, 1968-1975 continued on a part time basis until 1996.
  • Professor of Biochemistry, Chairman of the Department, University of Maastricht 1975-1999.
  • Rector Magnificus (Vice Chancellor) University of Maastricht 1982-1985.
  • Professeur Étranger Université René Descartes (Paris V) Hôpital Necker -Enfants Malades and Université. Pierre et Marie Curie (Paris VI), Hôpital Lariboisière 1984-1987.
  • Professeur Étranger Collège de France 1988.
  • Affiliate professor of Internal Medicine, Mount Sinai Medical School, New York.1995-2005

Main Distinctions and Awards

  • Prix Européen Ganassini (Milano) 1967
  • Boerhaave Medal (Leiden) 1974
  • Ernst Jung Price (Hamburg) 1985
  • Commandeur de l'Ordre des Palmes Académiques (France) 1987
  • Member of the Royal Dutch Academy of Arts and Sciences 1987
  • Career Award for contributions to Haemostasis and Thrombosis (ISTH) 1987
  • Medal of Honor Dutch Federation of Thrombosis Services 1989
  • Member of the Academia Europaea 1990
  • Chevalier de la Légion d'Honneur (France) 1990
  • Honorary member of the Royal Flemisch Academy 1991
  • Christiaan Huygens Lecture, Académie des Sciences, Paris 1992
  • Dutch Science Foundation, 8 year program grant 1993
  • Honorary Doctorate Xi’An Medical Faculty 1996
  • Honorary member of the Dutch Society of Thrombosis and Haemostasis 1997
  • Medal of the Medical Faculty Maastricht 1999
  • Knight of the order of "Nederlandse Leeuw" (Royal distinction, The Netherlands) 2000
  • Foreign member of the “Académie Nationale de Médecine” (France) 
  • Opening of the “Coen Hemker” lecture theatre at the University of Maastricht2009
  • Establishment “Hemker Fund” for fostering the Haemostasis and Thrombosis research at the university of Maastricht.2010
  • Officier de la Légion d’Honneur 2011
  • Medal of Merit of the City of Maastricht.2012

General

  • Author of over 500 scientific articles and several books.
  • Supervisor of over 60 Ph.D. theses.
  • Numerous editorial boards; among others 1980–2002 Haemostasis (Editor in Chief)

Scientific results

The scientific work of H. C. Hemker is almost entirely in the field of Haemostasis and Thrombosis research in which he is active since 1962. Since 1987 his research is centered around the development and application of thrombin generation as a tool in biochemical and pharmaceutical research and as an aid in the diagnosis and treatment of haemostatic- and thrombotic disorders.

Short summary of other scientific results:

  • Discovery of uncarboxylated clotting factors (PIVKAs) in vitamin K deficiency (Nature, 1963)
  • Discovery of the prothrombin converting enzyme as a complex of factors Xa,Va and phospholipid (Nature, 1968)
  • Discovery of the role of the antihaemophilic factors A and B as constituents of the factor X activating enzyme complex (Nature, 1968)
  • With J.Rosing: Discovery of the role of factor Va and phospholipid in the enzyme kinetics of prothrombin activation (JBC, 1980)
  • With Chr.Reutelingsberger: Discovery of Annexin V (Vascular AntiCoagulant, Eur J Biochem, 1985)
  • With W.Hermens: Development of ellipsometry as a tool in biochemistry of surface-bound reactions.(JBC, 1992-1999)
  • With S.Béguin: The mode of action of heparins in plasma, rationalisation of heparin determinations, development of standard-independent units for heparin activity. (Thrombosis and Haemostasis, 1987 - ongoing).
  • With T.Lindhout and W.Hermens: Thrombin formation at macroscopic surfaces (JBC, 1992-1999)
  • With S.Béguin: Discovery and development of the Endogenous Thrombin Potential (ETP) as a universal laboratory probe for hypercoagulability and the effect of anticoagulant drugs (Thrombosis and Haemostasis, 1987 - 1993).
  • With S.Béguin: Development of methods to determine the Thrombin Generation Curve in defibrinated platelet poor plasma automatically by conversion of special chromogenic substrates. (Thrombosis and Haemostasis, 1993-1998)
  • With S.Béguin: Discovery that fibrin can activate and provokes procoagulant activity in platelets (Thrombosis and Haemostasis, 1995-ongoing)
  • With S.Béguin: Discovery that von Willebrand factor plays a compulsory role in thrombin generation in platelet rich plasma, together with the receptors GPIIb/IIIa and GPIb (Thrombosis and Haemostasis, 1997-1999)
  • With J.Rosing: Discovery the biological variable in the clotting system that correlates with pill thrombosis (British Journal of Haematology, 1997-1999).
  • With S.Béguin and P.Giesen: Development of Calibrated Automated Thrombinography (CAT) a method to measure thrombin generation in real time in platelet poor or platelet rich plasma. (Thrombosis and Haemostasis, 2000-ongoing)
  • With P.W. Hemker and R. Wagenvoord: The possibilities and limits of mathematical simulation in blood coagulation research. (2005-ongoing)

Publications

Data management in thrombin generation. (2013)
Thromb Res. 2013 Jan;131(1):3-11.

Hemker HC, Kremers R.

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X. (2013)
J Thromb Haemost. 2013 Mar;11(3):503-11.

Al Dieri R, Bloemen S, Kelchtermans H, Wagenvoord R, Hemker HC.

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation. (2013)
Haematologica. 2013 Apr;98(4):549-54.

Bloemen S, Hemker HC, Al Dieri R.

Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: a rebuttal. (2013)
J Thromb Haemost. 2013 Mar;11(3):564.

Hemker HC, Béguin S.

Fluorogenic peptide-based substrates for monitoring thrombin activity. (2012)
ChemMedChem. 2012 Apr;7(4):606-17.

van Berkel SS, van der Lee B, van Delft FL, Wagenvoord R, Hemker HC, Rutjes FP.

Is there value in kinetic modeling of thrombin generation? No (unless). (2012)
J Thromb Haemost. 2012 Aug;10(8):1470-7.

Hemker HC, Kerdelo S, Kremers RM.

No effect of ethanol intake on thrombin generation parameters. (2012)
Thromb Res. 2012 Apr;129(4):530-1.

Bloemen S, Pieters M, Hemker HC, Al Dieri R.

Thrombin generation: what have we learned? (2012)
Blood Rev. 2012 Sep;26(5):197-203.

Al Dieri R, de Laat B, Hemker HC.

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay. (2012)
Clin Chem. 2012 Aug;58(8):1252-9.

Ninivaggi M, Apitz-Castro R, Dargaud Y, de Laat B, Hemker HC, Lindhout T.

[Thrombinoscopy: measuring thrombin generation]. (2011)
Ned Tijdschr Geneeskd. 2011;155:A2572.

Hemker HC.

Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens. (2011)
Menopause. 2011 Aug;18(8):873-9.

Scarabin PY, Hemker HC, Clément C, Soisson V, Alhenc-Gelas M.

Procoagulant effect of vitamin K antagonists? (2011)
J Thromb Haemost. 2011 Dec;9(12):2511-2.

Al Dieri R, Ten Cate-Hoek A, Bloemen S, Ten Cate H, Hemker HC.

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A. (2011)
J Thromb Haemost. 2011 Aug;9(8):1549-55.

Ninivaggi M, Dargaud Y, van Oerle R, de Laat B, Hemker HC, Lindhout T.

Thrombin generation is extremely sensitive to preheating conditions. (2011)
J Thromb Haemost. 2011 Jan;9(1):233-4.

De Smedt E, Hemker HC.

Data management in thrombin generation. (2013)
Thromb Res. 2013 Jan;131(1):3-11.

Hemker HC, Kremers R.

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay. (2010)
Thromb Res. 2010 Dec;126(6):531-5.

Debaugnies F, Azerad MA, Noubouossié D, Rozen L, Hemker HC, Corazza F, Efira A, Demulder A.

High subretinal fluid procoagulant activity in rhegmatogenous retinal detachment. (2010)
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5234-9.

Ricker LJ, Dieri RA, Beckers GJ, Pels E, Liem AT, Hendrikse F, Kijlstra A, Hemker HC, La Heij EC.

Monitoring new oral antithrombotics: what we should know before we can decide. (2010)
J Thromb Haemost. 2010 Dec;8(12):2833-5.

Al Dieri R, Hemker HC.

Monitoring platelet dependent thrombin generation in mice. (2010)
Thromb Res. 2010 Nov;126(5):436-41.

Dargaud Y, Spronk HM, Leenders P, Hemker HC, Ten Cate H.

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin. (2010)
J Thromb Haemost. 2010 Jun;8(6):1281-9.

Wagenvoord RJ, Deinum J, Elg M, Hemker HC.

Thrombin generation and plasma dilution. (2010)
Am J Clin Pathol. 2010 Jan;133(1):163; author reply 164.

Hemker HC, De Smedt E, Chandler WL, Roshal M.

The technique of measuring thrombin generation with fluorescent substrates: 4. The H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration. (2009)
Thromb Haemost. 2009 Jan;101(1):171-7.

Coen Hemker H, Hemker PW, Al Dieri R.

The technique of measuring thrombin generation with fluorogenic substrates: 3. The effects of sample dilution. (2009)
Thromb Haemost. 2009 Jan;101(1):165-70.

De Smedt E, Wagenvoord R, Coen Hemker H.

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths. (2008)
Thromb Res. 2008;122(2):237-45.

Wagenvoord R, Al Dieri R, van Dedem G, Béguin S, Hemker HC.

Recollections on thrombin generation. (2008)
J Thromb Haemost. 2008 Feb;6(2):219-26.

Hemker HC.

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration. (2008)
Thromb Haemost. 2008 Aug;100(2):343-9.

De Smedt E, Al Dieri R, Spronk HM, Hamulyak K, ten Cate H, Hemker HC.

Thrombin generation in whole blood. (2008)
Br J Haematol. 2008 Jun;141(6):895; author reply 896-7.

Al Dieri R, Hemker CH.

Caution in the interpretation of continuous thrombin generation assays : a rebuttal (2007)
J Thromb Haemost. 2007 5:1085-7.

Hemker, H. C.; De Smedt, E .

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system. (2007)
Thromb Haemost. 2007 Jun;97(6):938-43.

Eilertsen AL, Liestøl S, Mowinckel MC, Hemker HC, Sandset PM.

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk. (2007)
Haematologica. 2007 May;92(5):714-5.

Lecompte T, Wahl D, Perret-Guillaume C, Hemker HC, Lacolley P, Regnault V.

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis. (2007)
Inflamm Bowel Dis. 2007 Jun;13(6):753-8.

de Bièvre MA, Vrij AA, Schoon EJ, Dijkstra G, de Jong AE, Oberndorff-Klein Woolthuis AH, Hemker HC, Stockbrügger RW.

The contribution of alpha(2)-macroglobulin thrombin to the endogenous thrombin potential. (2007)
Br J Haematol. 2007 Nov;139(3):513.

Hemker HC, de Smedt E, Al Dieri R.

The initiation phase--a review of old (clotting-) times. (2007)
Thromb Haemost. 2007 Jul;98(1):20-3.

Hemker HC.

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin. (2007)
J Thromb Thrombolysis. 2007 Oct;24(2):175-82.

Vrij AA, Oberndorff-Klein-Woolthuis A, Dijkstra G, de Jong AE, Wagenvoord R, Hemker HC, Stockbrügger RW.

Age-dependency of thrombin generation. (2006)
Thromb Haemost. 2006 May;95(5):756-7.

Hemker HC, Al Dieri R.

Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight. (2006)
J Thromb Haemost. 2006 Jan;4(1):83-9.

Al Dieri R, Alban S, Béguin S, Hemker HC.

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection. (2006)
Pathophysiol Haemost Thromb. 2005;34(2-3):55-7.

Hemker HC, Ataullakhanov FI.

Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. (2006)
J Med Chem. 2006 Aug 24;49(17):5047-50.

De Nanteuil G, Gloanec P, Béguin S, Giesen PL, Hemker HC, Mennecier P, Rupin A, Verbeuren TJ.

Mathematical and biological models of blood coagulation. A rebuttal. (2006)
J Thromb Haemost. 2006 Mar;4(3):710-1.

Hemker HC, de Smedt E, Hemker PW.

New approaches for measuring coagulation. (2006)
Haemophilia. 2006 Jul;12 Suppl 3:76-81.

Barrowcliffe TW, Cattaneo M, Podda GM, Bucciarelli P, Lussana F, Lecchi A, Toh CH, Hemker HC, Béguin S, Ingerslev J, Sørensen B.

The limits of simulation of the clotting system. (2006)
J Thromb Haemost. 2006 Jun;4(6):1331-8.

Wagenvoord R, Hemker PW, Hemker HC.

Thrombin generation, a function test of the haemostatic-thrombotic system (2006)
Thromb Haemost. 2006 Nov;96(5):553-61.

Hemker HC, Al Dieri R, De Smedt E, Béguin S.

Calibrated automated thrombinography (CAT). (2005)
Thromb Res. 2005;115(3):255.

Hemker HC.

During coagulation, thrombin generation shifts from chemical to diffusional control. (2005)
J Thromb Haemost. 2005 Nov;3(11):2399-400.

Hemker HC, DE Smedt E, Hemker PW.

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. (2005)
Thromb Haemost. 2005 Mar;93(3):475-80.

Dargaud Y, Béguin S, Lienhart A, Al Dieri R, Trzeciak C, Bordet JC, Hemker HC, Negrier C.

Laboratory monitoring of low-molecular-weight heparin therapy--part II. Monitoring LMWH therapy? For the moment a non-question. (2005)
J Thromb Haemost. 2005 Mar;3(3):571-3.

Hemker HC, Al Dieri R, Béguin S.

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk. (2005)
Thromb Res. 2004;114(5-6):539-45.

Regnault V, Hemker HC, Wahl D, Lecompte T.

Wanneer moet men stollingsonderzoek verrichten binnen een familie? Welke bepalingen? Welke consequenties? (2005)
Vademecum permanente nascholing huisartsen

Hemker, H.C.

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available. (2004)
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1138-42.

Wielders SJ, Béguin S, Hemker HC, Lindhout T.

Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. (2004)
J Thromb Haemost. 2004 Jan;2(1):170-6.

uin S, Keularts I, Al Dieri R, Bellucci S, Caen J, Hemker HC.

Gekalibreerde, geautomatiseerde trombinegeneratiecurve : een nieuwe klinische functie-/screeningstest voor het integrale stollingssysteem (2004)
Nederlandsch tijdschrift voor geneeskunde 2004 20 november;148(47)

Keularts, I.M.L.W.; Beguin, S.; Hemker, H.C.

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics. (2004)
J Thromb Haemost. 2004 Mar;2(3):476-84.

Vanschoonbeek K, Feijge MA, Van Kampen RJ, Kenis H, Hemker HC, Giesen PL, Heemskerk JW.

The love of the artist for his model of thrombin generation. (2004)
J Thromb Haemost. 2004 Mar;2(3):400-1.

Hemker HC, Béguin S.

Thrombin generation assays: accruing clinical relevance. (2004)
Curr Opin Hematol. 2004 May;11(3):170-5.

Hemker HC, Al Dieri R, Béguin S.

Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time. (2004)
J Thromb Haemost. 2004 Aug;2(8):1395-401.

al Dieri R, Alban S, Béguin S, Hemker HC.

[The Choay domain -- the structure responsible for the anticoagulant action of heparins]. (2003)
Bull Acad Natl Med. 2003;187(1):59-66; discussion 66-7.

Hemker HC, al Dieri R, Wagenvoord R, Béguin S.

Calibrated automated thrombin generation in frozen-thawed platelet-rich plasma to detect hypercoagulability (2003)
Pathophysiol Haemost Thromb 2003;33:23-29

Regnault, Veronique; Beguin, Suzette; Lecompte, Thomas; Hemker, H. Coenraad

Calibrated automated thrombin generation measurement in clotting plasma. (2003)
Pathophysiol Haemost Thromb. 2003;33(1):4-15.

Hemker HC, Giesen P, Al Dieri R, Regnault V, de Smedt E, Wagenvoord R, Lecompte T, Béguin S.

Le domaine Choay : la structure responsable de l'activite anticoagulante des heparines = The Choay domain : the structure responsible for the anticoagulant action of heparins (2003)
Bull. Acad. Natle Méd.,2003, 187,n1 ,59-67

Hemker, H. Coenraad; Al Dieri, Raed; Wagenvoord, Rob; Beguin, Suzette

Phenotypage du systeme hemostatique par thrombinographie (2003)
Actualites THROMBOSE, 2003, 43, 1-7

Hemker, H. Coenraad

The inhibition of blood coagulation by heparins of different molecular weight is caused by a common functional motif--the C-domain. (2003)
J Thromb Haemost. 2003 May;1(5):907-14.

Al Dieri R, Wagenvoord R, van Dedem GW, Béguin S, Hemker HC.

The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets. (2003)
J Thromb Haemost. 2003 Feb;1(2):269-74.

Al Dieri R, Béguin S, Hemker HC.

Thrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants (2003)
Thromb Haemost 2003: 89: 208-12

Regnault, Veronique; Beguin, Suzette; Wahl, Denis; Maistre, de Emmanuel; Hemker, H. Coenraad

von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. (2003)
J Thromb Haemost. 2003 Mar;1(3):559-65.

Briedé JJ, Wielders SJ, Heemskerk JW, Baruch D, Hemker HC, Lindhout T.

Wanneer is een stollingsonderzoek geindiceerd bij routine preoperatief onderzoek? (2003)
Vademecum permanente nascholing huisartsen. 2003

Hemker, H.C.

Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWH. (2002)
Semin Thromb Hemost. 2002 Aug;28(4):369-78.

Alban S, Welzel D, Hemker HC.

The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. (2002)
Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):249-53.

Hemker HC, Giesen P, AlDieri R, Regnault V, de Smed E, Wagenvoord R, Lecompte T, Béguin S.

The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. (2002)
Thromb Haemost. 2002 Oct;88(4):576-82.

Al Dieri R, Peyvandi F, Santagostino E, Giansily M, Mannucci PM, Schved JF, Béguin S, Hemker HC.

Thrombin generation in a reconstituted system: a comment. (2002)
Thromb Haemost. 2002 Mar;87(3):551-4.

Hemker HC.

Thrombose beter te behandelen met 'ECG van de stolling' (2002)
N&T wetenschapsmagazine. 2002 Okt. 36-43

Hemker, Coen

An ionic contrast agent inhibits platelet-dependent thrombin generation and boosts the effect of abciximab. (2001)
Thromb Haemost. 2001 May;85(5):944-5.

Al Dieri R, de Muinck E, Hemker HC, Béguin S.

Contribution of platelet-derived factor Va to thrombin generation on immobilized collagen- and fibrinogen-adherent platelets. (2001)
Thromb Haemost. 2001 Mar;85(3):509-13.

Briedé JJ, Heemskerk JW, van't Veer C, Hemker HC, Lindhout T.

Low molecular weight heparin treatment in steroid refractory ulcerative colitis: clinical outcome and influence on mucosal capillary thrombi. (2001)
Scand J Gastroenterol Suppl. 2001;(234):41-7.

Vrij AA, Jansen JM, Schoon EJ, de Bruïne A, Hemker HC, Stockbrügger RW.

Regulation of platelet factor Va-dependent thrombin generation by activated protein C at the surface of collagen-adherent platelets. (2001)
J Biol Chem. 2001 Mar 9;276(10):7164-8.

Briedé JJ, Tans G, Willems GM, Hemker HC, Lindhout T.

The role of factor XI in thrombin generation induced by low concentrations of tissue factor. (2001)
Thromb Haemost. 2001 Jun;85(6):1060-5.

Keularts IM, Zivelin A, Seligsohn U, Hemker HC, Béguin S.

Bloedstollend (2000)
Verslag van de gewone vergadering van de Afdeling Natuurkunde der Koninklijke Nederlandse Akademie van Wetenschappen. 2000

Hemker, H.C.

Mitt todlicher Effizienz der Zukunft entgegen - oder: Der Atavismus des Gerinnungssystems (2000)
Die Innere Medizin an der Schwelle des neuen Jahrhunderts : Forschungsperspektiven in den Schwerpunktfaechern und flankierenden Disziplinen / Herausg. 2000

Hemker, H.C.; Beguin, S.

Phenotyping the clotting system. (2000)
Thromb Haemost. 2000 Nov;84(5):747-51.

Hemker HC, Béguin S.

The effect of DDAVP infusion on thrombin generation in platelet-rich plasma of von Willebrand type 1 and in mild haemophilia A patients. (2000)
Thromb Haemost. 2000 Oct;84(4):638-42.

Keularts IM, Hamulyak K, Hemker HC, Béguin S.

The thrombogram: monitoring thrombin generation in platelet-rich plasma. (2000)
Thromb Haemost. 2000 Apr;83(4):589-91.

Hemker HC, Giesen PL, Ramjee M, Wagenvoord R, Béguin S.

Acquired APC resistance and oral contraceptives: differences between two functional tests. (1999)
Br J Haematol. 1999 Apr;105(1):88-94.

Curvers J, Thomassen MC, Nicolaes GA, Van Oerle R, Hamulyak K, Hemker HC, Tans G, Rosing J.

Antithrombotic drugs (1999)
Emerging Drugs: The Prospect for Improved Medicines. Annual Executive Briefing 1999

Hemker, H. Coenraad; Giesen, Peter L.A.; Wagenvoord, Robert; Beguin, Suzette

Conjectures and refutations on the mode of action of heparins. The limited importance of anti-factor xa activity as a pharmaceutical mechanism and a yardstick for therapy. (1999)
Haemostasis. 1999;29(2-3):170-8.

Béguin S, Welzel D, Al Dieri R, Hemker HC.

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X. (1999)
Biochim Biophys Acta. 1999 Sep 14;1434(1):135-42.

Fernandez AZ, Tablante A, Beguín S, Hemker HC, Apitz-Castro R.

Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor. (1999)
Blood. 1999 Jan 15;93(2):564-70.

Béguin S, Kumar R, Keularts I, Seligsohn U, Coller BS, Hemker HC.

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets. (1999)
Biochim Biophys Acta. 1999 Aug 12;1451(1):163-72.

Briedé JJ, Heemskerk JW, Hemker HC, Lindhout T.

Inhibition of tissue factor-factor VIIa-catalyzed factor X activation by factor Xa-tissue factor pathway inhibitor. A rotating disc study on the effect of phospholipid membrane composition. (1999)
J Biol Chem. 1999 Oct 1;274(40):28225-32.

Salemink I, Franssen J, Willems GM, Hemker HC, Lindhout T.

The elevated risk for venous thrombosis in persons with hyperhomocysteinemia is not reflected by the endogenous thrombin potential. (1999)
Thromb Haemost. 1999 Mar;81(3):467-8.

Bos GM, Rijkers DT, Willems HP, den Heijer M, Béguin S, Gerrits WB, Hemker HC.

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin. (1998)
Biochemistry. 1998 Feb 3;37(5):1185-91.

Petrovan RJ, Govers-Riemslag JW, Nowak G, Hemker HC, Tans G, Rosing J.

Critical Perceptions on Problem-based Learning. (1998)
Adv Health Sci Educ Theory Pract. 1998;3(1):71-76.

Hemker HC.

Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. (1998)
Biochim Biophys Acta. 1998 Oct 23;1425(2):291-9.

Fernandez AZ, Tablante A, Bartoli F, Beguin S, Hemker HC, Apitz-Castro R.

Factor Xa cleavage of tissue factor pathway inhibitor is associated with loss of anticoagulant activity. (1998)
Thromb Haemost. 1998 Aug;80(2):273-80.

Salemink I, Franssen J, Willems GM, Hemker HC, Li A, Wun TC, Lindhout T.

Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. (1998)
J Immunol. 1998 Oct 15;161(8):4318-24.

Senden NH, Jeunhomme TM, Heemskerk JW, Wagenvoord R, van't Veer C, Hemker HC, Buurman WA.

Molecular biology and pathophysiology of APC resistance: current insights and clinical implications. (1998)
Semin Thromb Hemost. 1998;24(4):329-35.

Rosing J, Hemker HC, Tans G.

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density. (1998)
Thromb Res. 1998 Feb 15;89(4):161-9.

Rijkers DT, Wielders SJ, Béguin S, Hemker HC.

Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients. (1998)
Thromb Haemost. 1998 Sep;80(3):370-1.

Keularts IM, Béguin S, de Zwaan C, Hemker HC.

Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals. (1997)
Blood Coagul Fibrinolysis. 1997 Jan;8(1):28-38.

Nicolaes GA, Thomassen MC, Tans G, Rosing J, Hemker HC.

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways. (1997)
Biochemistry. 1997 Mar 18;36(11):3331-5.

Hoekema L, Nicolaes GA, Hemker HC, Tans G, Rosing J.

Laboratory assessment of antithrombotic therapy: what tests and if so why? (1997)
Haemostasis. 1997 Sep-Oct;27(5):211-8.

Kher A, Al Dieri R, Hemker HC, Béguin S.

Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third-generation oral contraceptives. (1997)
Br J Haematol. 1997 Apr;97(1):233-8.

Rosing J, Tans G, Nicolaes GA, Thomassen MC, van Oerle R, van der Ploeg PM, Heijnen P, Hamulyak K, Hemker HC.

Prothrombin conversion under flow conditions by prothrombinase assembled on adherent platelets. (1997)
Blood Coagul Fibrinolysis. 1997 Apr;8(3):168-74.

Billy D, Briedé J, Heemskerk JW, Hemker HC, Lindhout T.

Prothrombinase is protected from inactivation by tissue factor pathway inhibitor: competition between prothrombin and inhibitor. (1997)
Biochem J. 1997 Apr 1;323 ( Pt 1):33-7.

Franssen J, Salemink I, Willems GM, Wun TC, Hemker HC, Lindhout T.

Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom. (1997)
Thromb Res. 1997 Nov 1;88(3):309-16.

Petrovan RJ, Govers-Riemslag JW, Nowak G, Hemker HC, Rosing J, Tans G.

The activity of unfractionated heparin and low molecular weight heparins in rabbit plasma--the need for using absolute anti-factor Xa and antithrombin activities. (1997)
Thromb Haemost. 1997 Feb;77(2):312-6.

Peyrou V, Béguin S, Boneu B, Hemker HC.

The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling. (1997)
Eur J Biochem. 1997 Oct 15;249(2):547-55.

Heemskerk JW, Feijge MA, Henneman L, Rosing J, Hemker HC.

The routine determination of the endogenous thrombin potential, first results in different forms of hyper- and hypocoagulability. (1997)
Thromb Haemost. 1997 Apr;77(4):629-36.

Wielders S, Mukherjee M, Michiels J, Rijkers DT, Cambus JP, Knebel RW, Kakkar V, Hemker HC, Béguin S.

[Prevalence of hemorrhages caused by vitamin K deficiency in The Netherlands, 1992-1994]. (1996)
Ned Tijdschr Geneeskd. 1996 Jun 29;140(26):1378-9.

Hemker HC.

A prothrombinase-based assay for detection of resistance to activated protein C. (1996)
Thromb Haemost. 1996 Sep;76(3):404-10.

Nicolaes GA, Thomassen MC, van Oerle R, Hamulyak K, Hemker HC, Tans G, Rosing J.

Can the haemorrhagic component of heparin be identified? Or an attempt at clean thinking on a dirty drug. (1996)
Haemostasis. 1996 May-Jun;26(3):117-26.

Hemker HC, Béguin S, Kakkar VV.

Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis". (1996)
J Clin Invest. 1996 Aug 1;98(3):863-74.

Reverter JC, Béguin S, Kessels H, Kumar R, Hemker HC, Coller BS.

Prevalentie van bloedingen door vitamine K-tekort in Nederland, 1992-1994 (1996)
Ned Tijdschr Geneeskd. 1996 Juni; 140(26)

Hemker, H.C.

Synthesis of peptide p-nitroanilides mimicking fibrinogen- and hirudin-binding to thrombin. Design of slow reacting thrombin substrates. (1996)
Int J Pept Protein Res. 1996 Aug;48(2):182-93.

Rijkers DT, Hemker HC, Tesser GI.

"The endogenous thrombin potential, a new laboratory parameter to indicate the risk of thrombosis and its diminution by treatment (1996)
Challenges in Medicine Herausforderungedne r Medizin Symposium aus AnlaB des 100.G eburtstagevso n ErnStJ ung Challenges in Medicine. Herausforderungen der Medizin Symposium aus Anlaß des 100. Geburtstages von Ernst Jung. 1996

Hemker, H. Coenraad

" A convenient synthesis of amino acid p-nitroanilides : synthons in the synthesis of protease substrates (1995)
Tetrahedron Vol 51, No 41, pp. 11235-11250. 1995

Rijkers, Dirk R.S.; Adams, Hans P.H.M.; Hemker, H. Coenraad; Tesser, Godefridus I.

Aprotinin and hemostasis in cardiopulmonary bypass (1995)
Blood conservation with aprotinin / [edited by] Roque Pifarre. - hoofdstuk 12

Wildevuur, Ch.R.H.; Eijsman, L.; Hemker, H.C.

Design and synthesis of thrombin substrates with modified kinetic parameters. (1995)
Thromb Res. 1995 Sep 15;79(5-6):491-9.

Rijkers DT, Wielders SJ, Tesser GI, Hemker HC.

Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C. (1995)
J Biol Chem. 1995 Nov 17;270(46):27852-8.

Rosing J, Hoekema L, Nicolaes GA, Thomassen MC, Hemker HC, Varadi K, Schwarz HP, Tans G.

Inhibition of prothrombinase at macroscopic lipid membranes: competition between antithrombin and prothrombin. (1995)
Biochemistry. 1995 Oct 17;34(41):13699-704.

Billy D, Speijer H, Lindhout T, Hemker HC, Willems GM.

Inhibition of prothrombinase by antithrombin-heparin at a macroscopic surface. (1995)
Thromb Haemost. 1995 Apr;73(4):648-53.

Speijer H, Billy D, Willems G, Hemker HC, Lindhout T.

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. (1995)
J Biol Chem. 1995 Sep 8;270(36):21158-66.

Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J.

Production of thrombin as a probe for mixing of phospholipids in membranes on solid supports. (1995)
Biochim Biophys Acta. 1995 Jul 6;1237(1):43-8.

Giesen PL, Hemker HC, Hermens WT.

Prothrombin activation by prothrombinase in a tubular flow reactor. (1995)
J Biol Chem. 1995 Jan 20;270(3):1029-34.

lly D, Speijer H, Willems G, Hemker HC, Lindhout T.

Prothrombin contributes to the assembly of the factor Va-factor Xa complex at phosphatidylserine-containing phospholipid membranes. (1995)
J Biol Chem. 1995 Nov 10;270(45):26883-9.

Billy D, Willems GM, Hemker HC, Lindhout T.

Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus). (1995)
Thromb Haemost. 1995 Jan;73(1):94-100.

Apitz-Castro R, Béguin S, Tablante A, Bartoli F, Holt JC, Hemker HC.

The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity. (1995)
Thromb Haemost. 1995 Sep;74(3):962-8.

http://www.ncbi.nlm.nih.gov/pubmed/8571330

Thrombin generation in plasma: its assessment via the endogenous thrombin potential. (1995)
Thromb Haemost. 1995 Jul;74(1):134-8.

Hemker HC, Béguin S.

A chromogenic test to determine the procoagulant phospholipids in platelet-rich plasma and whole blood. (1994)
Thromb Haemost. 1994 Oct;72(4):582-7.

Wagenvoord RJ, Hendrix HH, Kai H, Hemker HC

Activation of human factor V by meizothrombin. (1994)
J Biol Chem. 1994 Jun 10;269(23):15969-72.

Tans G, Nicolaes GA, Thomassen MC, Hemker HC, van Zonneveld AJ, Pannekoek H, Rosing J.

Analysis of thrombin generation in plasma. (1994)
Comput Biol Med. 1994 Jul;24(4):277-88.

Kessels H, Willems G, Hemker HC.

Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions. (1994)
Arterioscler Thromb. 1994 May;14(5):824-30.

van Heerde WL, Sakariassen KS, Hemker HC, Sixma JJ, Reutelingsperger CP, de Groot PG.

Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain. (1994)
J Biol Chem. 1994 Aug 12;269(32):20662-7.

Bakker HM, Tans G, Thomassen MC, Yukelson LY, Ebberink R, Hemker HC, Rosing J.

Hemostasis and thrombosis (1994)
Laboratory medicine : the selection and interpretation of clinical laboratory studies / Dennis A. Noe, Robert C. Rock. 1994. pp. 236-53

Hemker, H.C.; Hamulyak, K.; Kessels, H.

Intrinsic and method-induced variation of the bleeding time and related parameters. (1994)
Thromb Haemost. 1994 Jun;71(6):798-9.

Kessels H, Kester AD, Hemker HC.

Kinetics of the inhibition of human factor Xa by full-length and truncated recombinant tissue factor pathway inhibitor. (1994)
Biochem J. 1994 Jan 1;297 ( Pt 1):131-6.

Lindhout T, Willems G, Blezer R, Hemker HC.

Measurement of thrombin generation in whole blood--the effect of heparin and aspirin. (1994)
Thromb Haemost. 1994 Jul;72(1):78-83.

Kessels H, Béguin S, Andree H, Hemker HC.

Mode of action of low molecular weight heparins in plasma and its consequences for the clinical laboratory (1994)
Low molecular weight heparins in prophylaxis and therapy of thromboembolic diseasses / ed. by Henri Bounameaux. 1994

Hemker, H. Coenraad; Beguin, Suzette

Nomenclature of quantities and units in thrombosis and haemostasis (Recommendation 1993) : a collaborative project of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis (ISTH/SSC)and the Commission/Committee on Quantaties and Units (in clinical chemistry)of the International Union of Pure and Applied Chemistry-International Federation of Clinical Chemistry ... (1994)
F. K. Schattauer Verslagsgesellschaft mbH ( Stuttgart) 71 (3) 375-94 (1994)

Blomback, M.; Abildgaard, U.; Besselaar, van den A.M.H.P.; Barrowcliffe, T.W.; Hemker, C.

Pharmacokinetics and pharmacodynamics of a low molecular weight heparin (enoxaparin) after subcutaneous injection, comparison with unfractionated heparin--a three way cross over study in human volunteers. (1994)
Thromb Haemost. 1994 Mar;71(3):305-13.

Bendetowicz AV, Béguin S, Caplain H, Hemker HC.

Pourquoi les schemas de coagulation sont-ils faux? (1994)
Sang Thrombose Vaisseaux 1994; 6: 619-625

Hemker, Henrik Coenraad; Beguin, Suzette

Sex-related difference in plasma von Willebrand factor (vWF:Ag and vWF:RiCof) levels in adolescenls (1994)
F. K. Schattauer Verslagsgesellschaft mbH ( Stuttgart) 71 (3) 799-800 (1994)

Kessels, Han; Kester, Arnold D.; Hemker, H. Coenraad

The effect of subcutaneous injection of unfractionated and low molecular weight heparin on thrombin generation in platelet rich plasma--a study in human volunteers. (1994)
Thromb Haemost. 1994 Nov;72(5):705-12.

Bendetowicz AV, Kai H, Knebel R, Caplain H, Hemker HC, Lindhout T, Béguin S.

The influence of fibrinogen and fibrin on thrombin generation--evidence for feedback activation of the clotting system by clot bound thrombin. (1994)
Thromb Haemost. 1994 Nov;72(5):713-21.

Kumar R, Béguin S, Hemker HC.

A generally applicable synthesis of amino acid p-nitroanilides as synthons (1993)
Peptides 1992 : proceedings of the twenty-second European Peptide Symposium September 13-19, 1992, Interlaken, Switzerland.

Rijkers, Dirk T.S.; Hemker, H. Coenraad; Nefkens, Gerard H.L.; Tesser, Godefidus I.

An investigation of the coagulogical potential of the venoms of some central asian snakes (1993)
Chemistry of natural compounds 1993. 29(3): 384-390.

Yukel'son, L. Ya.; Sadykov, E.S.; Barabanshchikova, N.A.; Rosing, J.; Hemker, H.C.

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight. (1993)
Thromb Res. 1992 Sep 15;67(6):665-76.

Tazi S, Tans G, Hemker HC, Nigretto JM.

Characterization of two forms of human factor Va with different cofactor activities. (1993)
J Biol Chem. 1993 Oct 5;268(28):21130-6.

Rosing J, Bakker HM, Thomassen MC, Hemker HC, Tans G.

Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. (1993)
Thromb Haemost. 1993 Oct 18;70(4):617-24.

Hemker HC, Wielders S, Kessels H, Béguin S.

Development of a rapid and sensitive chromogenic heparin assay for clinical use. (1993)
Haemostasis. 1993;23(1):26-37.

Wagenvoord RJ, Hendrix HH, Kolde HJ, Hemker HC.

Low molecular weight heparins - their mode of action in plasma and its consequences for the clinical laboratory (1993)
Vascular medicine. 1993.

Beguin, Suzette; Hemker, H. Coenraad

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry. (1993)
Biochim Biophys Acta. 1993 Apr 8;1147(1):125-31.

Giesen PL, Willems GM, Hemker HC, Stuart MC, Hermens WT.

Protein C activation by an activator purified from the venom of Agkistrodon halys halys. (1993)
Blood Coagul Fibrinolysis. 1993 Aug;4(4):605-14.

Bakker HM, Tans G, Yukelson LY, Janssen-Claessen TW, Bertina RM, Hemker HC, Rosing J.

Standard and method independent units for heparin anticoagulant activities. (1993)
Thromb Haemost. 1993 Nov 15;70(5):724-8.

Hemker HC, Béguin S.

The activity of heparin in the presence and absence of Ca2+ ions; why the anti-Xa activity of LMW heparins is about two times overestimated. (1993)
Thromb Haemost. 1993 Oct 18;70(4):717-8.

Hemker HC, Béguin S.

The influence of oral contraceptives on the time-integral of thrombin generation (thrombin potential). (1993)
Thromb Haemost. 1993 Dec 20;70(6):959-62.

Rotteveel RC, Roozendaal KJ, Eijsman L, Hemker HC.

The lnfluence of Oral Contraceptives on the Time-Integral of Thrombin Generation (Thrombin Potential) (1993)
VERWIJDEREN = dubbel

Rotteveel, R.C.; Roozendaal, K.J.; Eijsman, L.; Hemker, H.C.

[Thrombosis and thrombin]. (1992)
Ann Pharm Fr. 1992;50(3):121-35.

Hemker HC, Béguin S.

A rational approach to heparins. (1992)
Nouv Rev Fr Hematol. 1992;34(1):5-9.

Hemker HC, Béguin S.

Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells. (1992)
Blood. 1992 Jun 1;79(11):2909-16.

Lindhout T, Blezer R, Schoen P, Nordfang O, Reutelingsperger C, Hemker HC.

Anticoagulant mechanism of action of low molecular weight heparins (1992)
Low molecular weight heparins in clinical practice. 1992

Lindhout, Theo; Hemker, H. Coenraad

Clustering of lipid-bound annexin V may explain its anticoagulant effect. (1992)
J Biol Chem. 1992 Sep 5;267(25):17907-12.

Andree HA, Stuart MC, Hermens WT, Reutelingsperger CP, Hemker HC, Frederik PM, Willems GM.

Geneeskundig leven (1992)
De Gids. 1992. 155 (6) pp.505-511

Hemker, H.C.

Meccanismo d'azionee farmacocinetica degli anticoagulanti orali (1992)
La terapia anticoagulante orale: teoria e practica. 1992.

Marongiu, F.; Hemker, H.C.

On the relationship between molecular mass and anticoagulant activity in a low molecular weight heparin (enoxaparin). (1992)
Thromb Haemost. 1992 May 4;67(5):556-62.

Bendetowicz AV, Pacaud E, Béguin S, Uzan A, Hemker HC.

Ratios of anti-factor Xa to antithrombin activities of heparins as determined in recalcified human plasma. (1992)
Br J Haematol. 1992 Jun;81(2):255-62.

Schoen P, Lindhout T, Hemker HC.

The consumption of antithrombin III during coagulation, its consequences for the calculation of prothrombinase activity and the standardisation of heparin activity. (1992)
Thromb Haemost. 1992 Aug 3;68(2):136-42.

Béguin S, Kessels H, Dol F, Hemker HC.

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C. (1992)
Eur J Biochem. 1992 Aug 15;208(1):171-8.

Bakker HM, Tans G, Janssen-Claessen T, Thomassen MC, Hemker HC, Griffin JH, Rosing J.

The Consumption of antithrombin IIIduring coagulation, its consequences for the calculation of prothombinase activity and the standarisation of Heparin activity (1992)
Thrombosis and Haemostasis. E K. Schattauer Verlagsgesellschaft mbH (Stuttgart) 68 (2) 136-142 (1992).

Beguin, S.; Kessels, H.; Dol, F.; Hemker, H.C.

The mode of action of CY216 and CY222 in plasma. (1992)
Thromb Haemost. 1992 Jan 23;67(1):33-41.

Béguin S, Wielders S, Lormeau JC, Hemker HC.

The mode of action of heparins in vitro and in vivo. (1992)
Adv Exp Med Biol. 1992;313:221-30.

Hemker HC, Béguin S.

Thrombose et thrombine (1992)
Ann. pharmaceutiques francaises. 1992, 50 n3, pp. 121-135

Hemker, H.C.; Beguin, S.

Vertrouwen en wantrouwen in de geneeskunde en het recht (1992)
De Gids, 1992, Juli.

Hemker, H.C.

A method for measuring activated factor VIII in plasma. (1991)
Thromb Haemost. 1991 Oct 1;66(4):430-4.

Kessels H, Béguin S, Wagenvoord R, Hemker HC.

Annexin V (vascular anticoagulant alpha). Its mechanism of anticoagulation and its perspectives as a future antithrombotic drug (1991)
Immunologie und Blutgerinnung : XXXIII. Hamburger Symposion ueber Blutgerinnung am 15. und 16. Juni 1990

Andree, H.A.M.; Hemker, H.C.; Peltenburg, H.G.; Willems, G.; Reutelingsperger, C.P.M.

Determination of the levels of unfractionated and low-molecular-weight heparins in plasma: their effect on thrombin-mediated feedback reactions in vivo. Preliminary results after subcutaneous injection. (1991)
Haemostasis. 1991;21(4):258-72.

Hemker HC, Béguin S, Bendetowicz AV, Wielders S.

Elements from in vitro studies that help understand the action of heparins. (1991)
Thromb Res Suppl. 1991;14:1-10.

Hemker HC, Bendetowicz AV, Béguin S.

Factor IX a inhibition contributes to the heparin effect. (1991)
Thromb Haemost. 1991 Sep 2;66(3):306-9.

Béguin S, Dol F, Hemker HC.

Feedback activation of FVIII in plasma (1991)
2nd Symposium on new aspects of haemophilia treatment : January 28-30, 1991, Copenhagen, Denmark

Hemker, H.C.

Feedback mechanisms in coagulation. (1991)
Haemostasis. 1991;21(4):189-96.

Hemker HC, Kessels H.

Influence of lactobionic acid on the kinetics of thrombin in human plasma. (1991)
Semin Thromb Hemost. 1991;17 Suppl 1:126-8.

Béguin SS, Dol F, Hemker HC.

Low molecular weight heparin-catalyzed inactivation of factor Xa and thrombin by antithrombin III--effect of platelet factor 4. (1991)
Thromb Haemost. 1991 Oct 1;66(4):435-41.

Schoen P, Lindhout T, Franssen J, Hemker HC.

Mechanisme van de bloedstolling (1991)
Pharm Weekbl 1991;126(29):660-3.

Hemker, H.C.

Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma. (1991)
J Biol Chem. 1991 Nov 15;266(32):21864-73.

Tans G, Janssen-Claessen T, Hemker HC, Zwaal RF, Rosing J.

Membrane-mediated assembly of the prothrombinase complex. (1991)
J Biol Chem. 1991 Oct 5;266(28):18720-5.

Giesen PL, Willems GM, Hemker HC, Hermens WT.

Mode of action of heparin and related drugs. (1991)
Semin Thromb Hemost. 1991;17 Suppl 1:29-34.

Hemker HC, Beguin S.

Procoagulant activities in venoms from central Asian snakes. (1991)
Toxicon. 1991;29(4-5):491-502.

elson LY, Tans G, Thomassen MC, Hemker HC, Rosing J.

Simulation model for thrombin generation in plasma. (1991)
Haemostasis. 1991;21(4):197-207.

Willems GM, Lindhout T, Hermens WT, Hemker HC.

Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption. (1991)
J Biomater Sci Polym Ed. 1991;2(3):217-26.

Willems GM, Hermens WT, Hemker HC.

The use of phosphorus oxychloride in the synthesis of amino acid p-nitroanilides (1991)
Recl. Trav. Chim. Pays-Bas 110, 347-348 ( 1991).

Rijkers, D.T.S.; Hemker, H.C.; Nefkens, G.H.L.; Tesser, G.I.

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. (1990)
Lancet. 1990 Jun 30;335(8705):1544-7.

Galli M, Comfurius P, Maassen C, Hemker HC, de Baets MH, van Breda-Vriesman PJ, Barbui T, Zwaal RF, Bevers EM.

Anwendung der Ellipsometrie zur Untersuchung von Biomaterialien (1990)
H´┐Żmostaseologie 1990; 10: 71-76

Hemker, H.C.; Andree, H.A.M.; Giesen, P.L.A.

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. (1990)
J Biol Chem. 1990 Mar 25;265(9):4923-8.

Andree HA, Reutelingsperger CP, Hauptmann R, Hemker HC, Hermens WT, Willems GM.

Continuous flow and the prothrombinase-catalyzed activation of prothrombin. (1990)
Thromb Haemost. 1990 Dec 28;64(4):542-7.

Schoen P, Lindhout T, Willems G, Hemker HC.

Determination of heparin in blood (1990)
MED RAZGL 1990; 29: SPUUL 1: 95-110

Hemker, C.H.; Beguin, S.

Development of a sensitive and rapid chromogenic factor IX assay for clinical use. (1990)
Haemostasis. 1990;20(5):276-88.

Wagenvoord R, Hendrix H, Tran T, Hemker HC.

Is anti-factor Xa activity important? (1990)
J Lab Clin Med. 1990 Aug;116(2):268.

Hemker HC.

Mode of action of annexin V (vascular anticoagualnt alpha), a protein synthesized by the vessel wall (1990)
Journal of vacuum science and technology. 1990.

Gool, van Rein; Andree, Harry A.M.; Hemker, H. Coenraad; Reutelingsperger, Chris P.M.

Mode of action of enoxaparin in plasma. (1990)
Acta Chir Scand Suppl. 1990;556:51-6.

Béguin S, Hemker HC.

Mode of action of unfractionated and low molecular weight heparins on the generation of thrombin in plasma. (1990)
Haemostasis. 1990;20 Suppl 1:81-92.

Hemker HC, Béguin S.

The anticoagulant mechanism oa Action of heparin in plasma (1990)
Klinik und Forschung : Vortraege, AIDS-Symposium, Forschungsberichte. 1990

Hemker, H.C.; Pieters, J.; Beguin, S.; Lindhout, T.

The anticoagulant mechanism of action of recombinant hirudin (CGP 39393) in plasma. (1990)
Thromb Haemost. 1990 Nov 30;64(3):464-8.

Lindhout T, Blezer R, Hemker HC.

The thrombin potential a Parameter to Assess the effect of antithrombotic drugs on thrombin generation (1990)
Fraxiparine : Second International Symposium : recent pharmacological and clinical data. 1990

Hemker, H.C.; Wielders, S.; Beguin, S.

Thrombose en thrombine (1990)
Verslag van de gewone vergadering van de Afdeling Natuurkunde der Koninklijke Nederlandse Akademie van Wetenschappen. 99(6), 1990

Hemker, H.C.

A standard for low molecular weight heparin? (1989)
Haemostasis. 1989;19(1):1-4.

Hemker HC.

Antithrombin III-dependent anti-prothrombinase activity of heparin and heparin fragments. (1989)
J Biol Chem. 1989 Jun 15;264(17):10002-7.

Schoen P, Lindhout T, Willems G, Hemker HC.

Development of a simple chromogenic factor VIII assay for clinical use. (1989)
Haemostasis. 1989;19(4):196-204.

Wagenvoord RJ, Hendrix HH, Hemker HC.

Free factor Xa is on the main pathway of thrombin generation in clotting plasma. (1989)
Biochim Biophys Acta. 1989 Sep 15;992(3):409-11.

Hemker HC, Choay J, Beguin S.

Importance of factor-IX-dependent prothrombinase formation--the Josso pathway--in clotting plasma. (1989)
Haemostasis. 1989;19(6):301-8.

Xi M, Béguin S, Hemker HC.

In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma. (1989)
Blood. 1989 Aug 15;74(3):1021-4.

Pieters J, Lindhout T, Hemker HC.

Inhibition of phospholipid and platelet-dependent prothrombinase activity in the plasma of patients with lupus anticoagulants (1989)
British Journal of Haematology 1989, 72, 549-555

Galli, Monica; Beguin, Suzette; Lindhout, Theo; Hemker, Coenraad H.

The action of a synthetic pentasaccharide on thrombin generation in whole plasma. (1989)
Thromb Haemost. 1989 Jun 30;61(3):397-401.

Béguin S, Choay J, Hemker HC.

The effect of trace amounts of tissue factor on thrombin generation in platelet rich plasma, its inhibition by heparin. (1989)
Thromb Haemost. 1989 Feb 28;61(1):25-9.

Béguin S, Lindhout T, Hemker HC.

The ex vivo correlate of the antithrombotic action of heparin. (1989)
Ann N Y Acad Sci. 1989;556:146-57.

Hemker HC, Béguin S, Pieters J, Lindhout T.

The mechanisms of thrombin formation (1989)
Polymers: their properties and blood compatibility. 1989: 81-104

Beguin, S.; Devilee, P.P.; Hemker, H.C.

The mode of action of low molecular weight heparin preparation (PK10169) and two of its major components on thrombin generation in plasma. (1989)
Thromb Haemost. 1989 Feb 28;61(1):30-4.

Béguin S, Mardiguian J, Lindhout T, Hemker HC.

The relative importance of the factors II, VII, IX and X for the prothrombinase activity in plasma of orally anticoagulated patients. (1989)
Thromb Haemost. 1989 Sep 29;62(2):788-91.

Xi M, Béguin S, Hemker HC.

The search for antithrombotic therapy (1989)
Forschung auf dem Wege - Wege der Forschung : Symposium der Jung-Stiftung furr Wissenschaft und Forschung am 16. und 17. Mai 1987 in Hamburg. 1989

Hemker, H.C.

Antistollingsbehandeling (1988)
Wetenschappelijke Dienst (Roche). 1988

Hemker, H.C.; Hamulyak, K.; Beguin, S.

Characterization of gla-containing proteins from calcified human atherosclerotic plaques (1988)
Current advances in vitamin K research : proceedings of the seventeenth Steenbock symposium held June 21st through June 25th, 1987, at the University of Wisconsin-Madison, U.S.A.

Haarlem, van L. Johan M,; Soute, Berry A.M.; Hemker, H. Coenraad; Vermeer, Cees

Inhibition of factor IXa and factor Xa by antithrombin III/heparin during factor X activation. (1988)
J Biol Chem. 1988 Oct 25;263(30):15313-8.

Pieters J, Willems G, Hemker HC, Lindhout T.

Localization of the inhibitory site(s) of pentosan polysulphate in blood coagulation. (1988)
Thromb Haemost. 1988 Oct 31;60(2):220-5.

Wagenvoord R, Hendrix H, Soria C, Hemker HC.

Purification and characterization of a novel protein from bovine aorta that inhibits coagulation. Inhibition of the phospholipid-dependent factor-Xa-catalyzed prothrombin activation, through a high-affinity binding of the anticoagulant to the phospholipids. (1988)
Eur J Biochem. 1988 Apr 5;173(1):171-8.

Reutelingsperger CP, Kop JM, Hornstra G, Hemker HC.

The heparin-catalysed inhibition of human factor XIa by antithrombin III is dependent on the heparin type. (1988)
Biochem J. 1988 Dec 15;256(3):815-20.

Soons H, Tans G, Hemker HC.

The mode of action of heparin in plasma. (1988)
Thromb Haemost. 1988 Dec 22;60(3):457-62.

Béguin S, Lindhout T, Hemker HC.

The prolongation of the thrombotest clotting time in newborns. (1988)
Thromb Res. 1988 Oct 1;52(1):45-52.

Hamulyák K, Devilée PP, Nieuwenhuizen W, Hemker HC.

Adsorption kinetics of protein mixtures. A tentative explanation of the Vroman effect. (1987)
Ann N Y Acad Sci. 1987;516:244-52.

Cuypers PA, Willems GM, Hemker HC, Hermens WT.

Coagulation et fibrinolyse : de la formation a la dissolution du caillot (1987)
Le Sang et les Vaisseaux. 1987: pp.3-29.

Soria, Claudine; Hemker, Coen

Inhibition of factor XIa by antithrombin III. (1987)
Biochemistry. 1987 Jul 28;26(15):4624-9.

Soons H, Janssen-Claessen T, Tans G, Hemker HC.

Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae. (1987)
Biochem J. 1987 Jul 1;245(1):251-5.

Van Haarlem LJ, Ulrich MM, Hemker HC, Soute BA, Vermeer C.

Spectrophotometric method for the assay of human blood coagulation factor VIII. (1987)
Haemostasis. 1987;17(1-2):14-24.

van Dieijen G, van Dieijen-Visser MP, Franssen J, Hemker HC.

The activity state of factor VII in plasma: two pathways for the cold promoted activation of factor VII (1987)
British Journal of Haematology 1986, 62, 367-377.

Muller, A.D.; Deijk, W.A.; Devilee, P.P.; Dam-Mieras, Van M.C.E.; Hemker, H.C.

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene. (1987)
Eur J Biochem. 1987 Apr 15;164(2):337-43.

van de Waart P, Visser AJ, Hemker HC, Lindhout T.

The placental transport of [3H]vitamin K1 in rats. (1987)
Br J Haematol. 1987 Mar;65(3):335-8.

Hamulyák K, de Boer-van den Berg MA, Thijssen HH, Hemker HC, Vermeer C.

[A patient with a viper bite]. (1986)
Ned Tijdschr Geneeskd. 1986 Nov 8;130(45):2048.

Hemker HC, Kamulyák K.

A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. (1986)
Thromb Haemost. 1986 Aug 20;56(1):9-17.

Hemker HC, Willems GM, Béguin S.

Anticoagulants oraux (1986)
Pharmacologie Clinique. Sem Hop Paris. 1986 Jan.

Hemker, H.C.; Thijssen, H.H.W.

Arvin, een nieuw anticoagulans (1986)
Nederlands tijdschrif voor Geneeskunde. 1968 Okt. 112 nr 43

Hemker, H.C.; Loeliger, E.A.

Heparine (1986)
Pharmacologie Clinique. Sem Hop Paris. 1986 Feb.

Hemker, H.C.; Fischer, A.M.; Cornu, P.

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III. (1986)
Haemostasis. 1986;16(2):71-81.

Baruch D, Lindhout T, Wagenvoord R, Hemker HC.

Interplay between medicine and biochemistry (1986)
Blood Coagulation, 1986.

Hemker, H. Coenraad

Kinetics of thrombin-induced release and activation of platelet factor V. (1986)
Eur J Biochem. 1986 Jan 2;154(1):213-8.

Baruch D, Hemker HC, Lindhout T.

Kurzfassung des Referats Neue Entwicklungen im Grenzbereich von Gerinnungsbiochemie und Gerinnungspathologie (1986)
Mitteilungen / [Hrsg.] Deutsche Gesellschaft fuer Klinische Chemie e.V. 1986. (3)

Hemker, H.C.

Prolein adsorption at the solid-liquid interface measured by ellipsometry (1986)
Blood compatible materials and their testing. 1986

Cuypers, P.A.; Hemker, H.C.; Hermens, W. Th.

Protrombinetijden en thrombotest bij antistollingsbehandeling (1986)
Nederlands tijdschrif voor Geneeskunde. 1968 Nov. 112 nr 43

Loeliger, E.A.; Hemker, H.C.

Role of accessory components in the activation of vitamin K-dependent coagulation factors. (1986)
Haemostasis. 1986;16(3-4):216-26.

van Rijn JL, Zwaal RF, Hemker HC, Rosing J.

The effect of platelets in the activation of human blood coagulation factor IX by factor XIa. (1986)
Blood. 1986 Jul;68(1):140-8.

Soons H, Janssen-Claessen T, Hemker HC, Tans G.

Thrombin generation and inactivation in the presence of antithrombin III and heparin. (1986)
Biochemistry. 1986 Oct 7;25(20):5962-9.

Lindhout T, Baruch D, Schoen P, Franssen J, Hemker HC.

Thrombosis and thrombin (1986)
Biology and Pathology of Platelet-Vessel Wall Interactions. 1986.

Hemker, H.C.; Beguin, S.

[The treatment of podotrochilosis with oral anticoagulants. An instruction insert desired]. (1985)
Tijdschr Diergeneeskd. 1985 Aug 15;110(15-16):585-95.

van den Bogaard AE Jr, Thijssen HH, Hemker HC.

Assembly of the intrinsic factor X activating complex--interactions between factor IXa, factor VIIIa and phospholipid. (1985)
Thromb Haemost. 1985 Jun 24;53(3):396-400.

van Dieijen G, van Rijn JL, Govers-Riemslag JW, Hemker HC, Rosing J.

Clotting factors secreted by monocytes and macrophages: analytical considerations. (1985)
Thromb Res. 1985 Jan 1;37(1):9-19.

van Dam-Mieras MC, Muller AD, van Deijk WA, Hemker HC.

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients. (1985)
Thromb Res. 1985 Jan 15;37(2):295-307.

Fischer AM, Dautzenberg MD, Aurousseau MH, Béguin S, Goudemand J, Hemker HC.

De behandeling van podotrochleose met orale anticoagulantia : een bijsluiter gewenst (1985)
Tijdschr. Diergeneeskd., deel 110, afl. 15/ 16, 1985.

Boogaard, van den A.E.J.M.; Thijssen, H.H.W.; Hemker, H.C.

Effect of heparin and low molecular weight heparins on thrombin-induced blood platelet activation in the absence of antithrombin III. (1985)
Thromb Res. 1985 Jun 1;38(5):447-58.

Baruch D, Franssen J, Hemker HC, Lindhout T.

Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder. (1985)
Blood. 1985 Jun;65(6):1557-61.

Rosing J, Bevers EM, Comfurius P, Hemker HC, van Dieijen G, Weiss HJ, Zwaal RF.

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. (1985)
Eur J Biochem. 1985 Sep 16;151(3):625-9.

Reutelingsperger CP, Hornstra G, Hemker HC.

Measurement of macrophage cellular procoagulant activity. (1985)
Haemostasis. 1985;15(2):108-13.

Muller AD, van Dam-Mieras MC, Hemker HC.

The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. (1985)
Verh K Acad Geneeskd Belg. 1985;47(5):321-39.

Hemker HC, Béguin S.

The mechanism of action of oral anticoagulants and its consequences for the practice of oral anticoagulation. (1985)
Haemostasis. 1985;15(4):263-70.

Hemker HC, Frank HL.

Vitamin K-dependent carboxylase: the carboxylation of exogenous substrates in different systems. (1985)
Biochim Biophys Acta. 1985 Sep 20;831(1):94-8.

de Boer-van den Berg MA, Ulrich MM, Hemker HC, Soute BA, Vermeer C.

[Oral anticoagulant treatment; which anticoagulant?]. (1984)
Ned Tijdschr Geneeskd. 1984 Aug 18;128(33):1559-63.

Thijssen HH, Hemker HC.

A clotting scheme for 1984. (1984)
Nouv Rev Fr Hematol. 1984;26(4):227-31.

Hemker HC, Lindhout T.

Activation of coagulation and fibrinolysis during maximal physicat exercise (1984)
International journal of sports medicine. (1984)6 4-65 Supplement

Hamulyak, K.; Brommer, E.J.P.; Devilee, P.P.; Hemker, H.C.

Automated determination of heparin with chromogenic substrates. (1984)
Haemostasis. 1984;14(2):184-94.

van Putten J, van de Ruit M, Beunis M, Hemker HC.

Automated spectrophotometric heparin assays. Comparison of methods. (1984)
Haemostasis. 1984;14(2):195-204.

van Putten J, van de Ruit M, Beunis M, Hemker HC.

Blood coagulation as a biochemical sytem (1984)
Thrombose- und Haemostaseforschung 1984

Hemker, H.C.; Frank, H.L.L.

Blood coagulation factors II, V, VII, VIII, IX, X and XI: determination by clotting assay (1984)
Methods of enzymatic analysis. 1984 - vol 5: Enzymes 3: Peptidases, proteinases and their inhibitors

Dam-Mieras, van Maria C.E.; Muller, Annemarie D.; Hemker, H. Coenraad

Determination of low molecular weight heparin in clinical laboratory. (1984)
Haemostasis. 1984;14(2):205-10.

van Putten J, van de Ruit M, Beunis M, Hemker HC.

Functional properties of factor Va subunits after proteolytic alterations by activated protein C. (1984)
Biochim Biophys Acta. 1984 May 25;799(1):38-44.

Van de Waart P, Bruls H, Hemker HC, Lindhout T.

Heparin neutralization during collection and processing of blood inhibited by pyridoxal 5'-phosphate. (1984)
Haemostasis. 1984;14(3):253-61.

van Putten J, van de Ruit M, Beunis M, Hemker HC.

In memory of François Josso. Why do hemophiliacs bleed? (1984)
Scand J Haematol Suppl. 1984;40:11-9.

Hemker HC.

Interaction of prothrombin with factor Va-phospholipid complexes. (1984)
Biochemistry. 1984 Jun 5;23(12):2838-42.

van de Waart P, Hemker HC, Lindhout T.

Letter to the editors-in-chief : on the procoagulant activity of platelets stimulated by collagen and thrombin (1984)
Thrombosis Research 1984; 553-554

Bevers, E.M.; Comfurius, P.; Hemker, H.C.; Zwaal, R.F.A.

On the procoagulant activity of platelets stimulated by collagen and thrombin. (1984)
Thromb Res. 1984 Mar 1;33(5):553-4.

Bevers EM, Comfurius P, Hemker HC, Zwaal RF.

The action of Echis carinatus venom on the blood coagulation system. Demonstration of an activator of factor X. (1984)
Thromb Res. 1984 Jul 1;35(1):1-9.

Hemker HC, van Dam-Mieras MC, Devilée PP.

The adsorption of prothrombin to phospholipid monolayers quantitated by ellipsometry. (1984)
J Biol Chem. 1984 Nov 25;259(22):13993-8.

Kop JM, Cuypers PA, Lindhout T, Hemker HC, Hermens WT.

The inhibition of platelet prothrombinase activity by prostacyclin. (1984)
Haemostasis. 1984;14(4):320-4.

Zwaal RF, Comfurius P, Hemker HC, Bevers EM.

About the cost of Opposing the Goumarin-inhibitor theory-reply (1983)
Thrombosis and Haemostasis.1983 Jun. Vol. 49 No.3

Hemker, H.C.

Activation of human prothrombin by stoichiometric levels of staphylocoagulase. (1983)
J Biol Chem. 1983 Mar 25;258(6):3637-44.

Hendrix H, Lindhout T, Mertens K, Engels W, Hemker HC.

Controle van orale antistollingstherapie met behulp van chromogene bepalingen voor de factoren II, VII, IX en X (1983)
Thrombose: diagnostiek, preventie en behandeling. 1982; pp 228-231

Dieijen-Visser, van M.P.; Wersch, van J.; Brombacher, P.J.; Rosing, J.; Hemker, H.C.

Evaluation of a coagulation assay determining the activity state of factor VII in plasma. (1983)
Haemostasis. 1983;13(3):192-7.

van Deijk WA, van Dam-Mieras MC, Muller AD, Hemker HC.

Half-life time and control frequency of vitamin K-dependent Coagulation factors. Theoretical considerations on the place of factor VII in the control of oral anticoagulation therapy. (1983)
Haemostasis. 1983;13(3):201-8.

van Dam-Mieras MC, Hemker HC.

Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles. (1983)
Biochemistry. 1983 May 10;22(10):2427-32.

van de Waart P, Bruls H, Hemker HC, Lindhout T.

Platelet membrane involvement in blood coagulation. (1983)
Blood Cells. 1983;9(2):303-17.

Hemker HC, van Rijn JL, Rosing J, van Dieijen G, Bevers EM, Zwaal RF.

Reduction of infarct size: discrepancies between experimental work and clinical application (1983)
International journal of cardiology, 2 (1983) 347-348

Hermens, W. Th.; Hemker, H.C,

Reevaluation of some properties of fibrinogen, purified from cord blood of normal newborns. (1983)
Thromb Res. 1983 Nov 1;32(3):301-10.

Hamulyák K, Nieuwenhuizen W, Devilée PP, Hemker HC.

Stimulation of the vitamin K-dependent carboxylase from bovine liver. (1983)
Biochem J. 1983 Mar 1;209(3):719-24.

De Metz M, Soute BA, Hemker HC, Vermeer C.

The adsorption of prothrombin to phosphatidylserine multilayers quantitated by ellipsometry. (1983)
J Biol Chem. 1983 Feb 25;258(4):2426-31.

Cuypers PA, Corsel JW, Janssen MP, Kop JM, Hermens WT, Hemker HC.

The interaction between blood platelets and blood coagulation factors (1983)
Arzneim. -Forsch. /Drug Res. 33 (II),9a, 1365-1369 (1983)

Rijn, van J.L.M.L.; Rosing, J.; Dieijen, van G.; Bevers, E.M.; Zwaal, R.F.A.; Hemker, H.C.

The role of factors VIII and IX in blood coagulation (1983)
Current topics in haemophilia. 1983; 99 3-14

Dieijen, van G.; Rosing, J.; Rijn, van J.; Bevers, E.; Hemker, H.C.

[Formation and functions of thrombin]. (1982)
Ned Tijdschr Geneeskd. 1982 Jan 30;126(5):198-203.

Hemker HC.

A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows (1982)
Biochimica et Biophysica Acta,714 (1982) 361-365.

Vermeer, C.; Soute, B.A.M.; De Metz, M.; Hemker, H.C.

Activation of factor IX by factor XIa--a spectrophotometric assay for factor IX in human plasma. (1982)
Thromb Haemost. 1982 Oct 29;48(2):127-32.

Tans G, Janssen-Claessen T, van Dieijen G, Hemker HC, Rosing J.

Blood cell membranes and haemostasis. (1982)
Haemostasis. 1982;11(1):12-39.

Zwaal RF, Hemker HC.

Factor Va-factor Xa interaction. Effects of phospholipid vesicles of varying composition. (1982)
Biochemistry. 1982 Oct 26;21(22):5494-502.

Lindhout T, Govers-Riemslag JW, van de Waart P, Hemker HC, Rosing J.

Francois Josso, 1927 -1981 (1982)
Nouvelle Revue Francaise d Hematologie (1982)24:103.

Hemker, Coen

Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. (1982)
Eur J Biochem. 1982 Feb;122(2):429-36.

Bevers EM, Comfurius P, van Rijn JL, Hemker HC, Zwaal RF.

Heterogeneous biocatalysis in the generation of thrombin (1982)
Trends in Biochemical Sciences - October, 1982 Vol. 7, No. 10, pp. 378- 381.

Hemker, H.C.; Zwaal, R.F.A.

In memoriam : Francois Josso 1927-1981 (1982)
Haemostastis. 1982;11(1), p.1

Hemker, Coen; Beguin, Suzette

Interindividual variation in relationships between plasma heparin concentration and the results of five heparin assays. (1982)
Clin Chim Acta. 1982 Jul 1;122(2):261-70.

van Putten J, van de Ruit M, Beunis M, Hemker HC.

On the clot-promoting activity of human platelets in a one-stage prothrombinase assay. (1982)
Haemostasis. 1982;12(3):268-74.

Bevers EM, Comfurius P, Hemker HC, Zwaal RF.

Oral administration of factor Vlll in lipid vesicles (1982)
Unresolved problems in haemophilia : proceedings of an international symposium held at the Royal College of Physicians and Surgeons, Glasgow, September 1980

Hemker, H.C.; Zwaal, R.F.A.

Pekelharing en het beriberi-onderzoek : reactie (1982)
Nederlandsch tijdschrift voor geneeskunde. 1982; 126(42)

Hemker, C.W.

Spectrophotometric assays in the control of oral anticoagulant therapy (1982)
7th ICTH. 1982;12(5)

Dieijen-Visser, van M.P.; Wersch, van J.; Brombacher, P.J.; Rosing, J.; Hemker, H.C.; Dieijen, van G.

Studies on the mechanism of the vitamin K-dependent carboxylation reaction. Carboxylation without the concurrent formation of vitamin K 2,3-epoxide. (1982)
J Biol Chem. 1982 May 25;257(10):5326-9.

de Metz M, Soute BA, Hemker HC, Fokkens R, Lugtenburg J, Vermeer C.

The biochemistry of blood coagulation (1982)
Developments in hematology and immunology. 1982 vol.5

Hemker, H.C.

The inhibition of vitamin K-dependent carboxylase by cyanide. (1982)
FEBS Lett. 1982 Jan 25;137(2):253-6.

De Metz M, Soute BA, Hemker HC, Vermeer C.

Use of chromogenic peptide substrates in the determination of clotting factors II, VII, IX and X in normal plasma and in plasma of patients treated with oral anticoagulants. (1982)
Haemostasis. 1982;12(3):241-55.

van Dieijen-Visser MP, van Wersch J, Brombacher PJ, Rosing J, Hemker HC, van Dieijen G.

Vorming en functies van trombine (1982)
Nederlands tijdschrift voor geneeskunde. 126(5).

Bohn, Scheltema & Holkema

Identification of phospholipid as an essential part of bovine vitamin K-dependent carboxylase. (1981)
J Biol Chem. 1981 Nov 10;256(21):10843-6.

de Metz M, Vermeer C, Soute BA, Hemker HC.

In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin. (1981)
Biochim Biophys Acta. 1981 Aug 5;676(1):101-7.

Soute BA, Vermeer C, De Metz M, Hemker HC, Lijnen HR.

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue. (1981)
Haemostasis. 1981;10(6):315-47.

Van der Woerd-de Lange JA, van Dam-Mieras MC, Hemker HC.

Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X. (1981)
FEBS Lett. 1981 Jan 26;123(2):215-8.

de Metz M, Vermeer C, Soute BA, van Scharrenburg GJ, Slotboom AJ, Hemker HC.

The role of phospholipid and factor VIIIa in the activation of bovine factor X. (1981)
J Biol Chem. 1981 Apr 10;256(7):3433-42.

van Dieijen G, Tans G, Rosing J, Hemker HC.

Thrombosis service in the Netherlands (1981)
International Journal of Cardiology, 1 (1981) 215-216

Hemker, H.C.

Bloedstolling (1980)
Compitum. 1980

Dam-Mieras, van M.C.E.; Hemker, H.C.

Blood coagulation, an example of heterogeneous biokatalysis (1980)
Archives internationales de physiologie et de biochimie, 88 (2)

Hemker, H.C.

Blood-clotting enzymology : the activation of factor X by factor IXa : the effect of phospholipid and of antihaemophilia factor VIII (F VIII) on the activation reaction (1980)
Archives internationales de physiologie et de biochimie, 88 (3)

Dieijen, van G.; Rosing, J.; Tans, G.; Janssen-Claessen, G.; Franssen, J.; Hemker, H.C.

Conjectures on the mode of action of factors V and Vlll (1980)
The regulation of coagulation. 1980.

Tans, G.; Rosing, J.; Dieyen, G.V.; Hemker, H.C.

Contribution of the platelet factor V content to platelet factor 3 activity. (1980)
Br J Haematol. 1980 May;45(1):121-31.

van Zutphen H, Bevers EM, Hemker HC, Zwaal RF.

Culinaire aspecten van de voeding (1980)
Voeding (1980). pp. 102-106.

Hemker, H.C.

On the role of phospholipids in the reaction mechanism of blood coagulation (1980)
Protides of the biological fluids. (1980) pp.265-671.

Hemker, H.C.; Dieijen, van G.; Rosing, J.; Tans, G.; Zwaal, R.F.A.

Oral administration of factor VIII : report of first consultant visit to G.C.C. and suggestions for future research (1980)
Report of first consultant visit to G.C.C. And suggestions for future research. (1980).

Hemker, H.C.; Zwaal, R.F.A.

Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes. (1980)
Lancet. 1980 Jan 12;1(8159):70-1.

Hemker HC, Hermens WT, Muller AD, Zwaal RF.

Temperatured dependent transitions in several phospholipids measured by ellipsometry (1980)
Surface Science 96 (1980) 555-563

Cuypers, P.A.; Janssen, M.P.; Kop, J.M.M.; Hermens, W.TH.; Hemker, H.C.

The carboxylation of prothrombin precursors in a bovine liver cell-free system (1980)
Protrids of biological fluids. - 28th colloquium. (1980).

Vermeer, C.; DE Metz, M.; Soute, B.A.M.; Hemker, H.C.

The role of phospholipids and factor Va in the prothrombinase complex. (1980)
J Biol Chem. 1980 Jan 10;255(1):274-83.

Rosing J, Tans G, Govers-Riemslag JW, Zwaal RF, Hemker HC.

Topological and kinetic aspects of phospholipids in blood coagulation (1980)
The regulation of coagulation. (1980) Vol 8.

Zwaal, R.F.A.; Rosing, J.; Tans, G.; Bevers, E.M.; Hemker, H.C.

[The inhibition of coagulation in cord plasma (author's transl)]. (1979)
Z Geburtshilfe Perinatol. 1979 Apr;183(2):163-8.

Kirchhof BR, Hoheisel M, Keefer L, Hemker HC.

A coagulation reagent completely devoid of factor X; relation between clotting time and concentration of factor X. (1979)
Thromb Res. 1979;14(4-5):679-85.

Vermeer C, Soute BA, Hemker HC.

An inhibitor of clot formation in cord plasma. (1979)
Thromb Res. 1979;15(3-4):389-403.

Kirchhof BR, Muller AD, Hemker HC.

Clot-promoting effect of platelet-vessel wall interaction: influence of dietary fats and relation to arterial thrombus formation in rats. (1979)
Haemostasis. 1979;8(3-5):211-26.

Hornstra G, Hemker HC.

Control of anticoagulant therapy with a chromogenic substrate. (1979)
Haemostasis. 1979;8(1):1-7.

Kirchhof BR, Muller AD, Vermeer C, Hemker HC.

Hemmung der Gerinnung in Nabelschnurvenenplasma (1979)
Zeitschrift fuer Geburtshilfe und Perinatologie. 1979: 183(2).

Kirchhof, B.R.J.; Hoheisel, M.; Keefer, L.; Hemker, H.C.

Kinetic aspects of the interaction of blood clotting enzymes : the relation between clotting time and clotting velocity (1979)
Thrombosis and haemostasis. 1979 Apr. No 2, Vol 41

Hemker, H.C.; Kop, J.; Willems, G.M.

Kinetic aspects of the interaction of blood clotting enzymes. VIII. The relation between clotting time and clotting velocity. (1979)
Thromb Haemost. 1979 Apr 23;41(2):309-13.

Hemker HC, Kop J, Willems GM.

Lipid phase transitions and procoagulant activity. (1979)
Eur J Biochem. 1979 Apr;95(3):449-57.

Tans G, van Zutphen H, Comfurius P, Hemker HC, Zwaal RF.

A quick method for the determination of decarboxyfactor X. (1978)
Thromb Res. 1978 Jun;12(6):1071-8.

Vermeer C, Soute BA, Hemker HC.

Activation of decarboxyfactor X by a protein from Russell's viper venom. Purification and partial characterization of activated decarboxyfactor X. (1978)
Biochim Biophys Acta. 1978 Apr 26;533(2):327-41.

Lindhout MJ, Kop-Klaassen BH, Hemker HC.

Computer evaluation of reference curves for the estimation of extrinsic coagulation factors. (1978)
Comput Biol Med. 1978 Jan;8(1):65-70.

Frank HL, Dreessen V, Hemker HC.

COomputer evaluation of reference curves for the estimation of extrinsic coagulation factors (1978)
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Frank, H.L.L.; Dreessen, V.; Hemker, H.C.

Ellipsometry as a tool to study protein films at liquid-solid interfaces. (1978)
Anal Biochem. 1978 Jan;84(1):56-67.

Cuypers PA, Hermens WT, Hemker HC.

Gezonde fijne keuken (1978)
Hart Bullletin. 2:26-27,1978

Zeguers, J.; Frank, H.L.L.; Hemker, H.C.

Gezonde fijne keuken : einde en begin (1978)
Hart Bulletin 9:45-46, 1978

Hemker, H.C.

Improvements of the method for the preparation of an artificial prothrombin reagent. (1978)
Thromb Res. 1978 Apr;12(4):713-6.

Vermeer C, Soute BA, Hemker HC.

In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase. (1978)
Biochim Biophys Acta. 1978 Apr 12;523(2):494-505.

Vermeer C, Soute BA, Hemker HC.

Purification and properties of the phenprocoumon-induced decarboxyfactor X from bovine plasma. A comparison to normal factor X. (1978)
Biochim Biophys Acta. 1978 Apr 26;533(2):302-17.

Lindhout MJ, Kop-Klaassen BH, Kop JM, Hemker HC.

Stolling en antistolling : het onderzoek in Leiden en Maastricht (1978)
TNO Project 6(78) 242-245

Hemker, H.C.

The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator. (1978)
Thromb Res. 1978 Aug;13(2):219-32.

Kirchhof BR, Vermeer C, Hemker HC.

The effect of gamma-carboxyglutamate residues on the enzymatic properties of the activated blood clotting factor X. I. Activity towards synthetic substrates. (1978)
Biochim Biophys Acta. 1978 Apr 26;533(2):342-54.

Lindhout MJ, Kop-Klaassen BH, Hemker HC.

The kinetic behaviour of active sites present in a structured environment (1978)
Journal of Molecular Medicine, 3 (1978) 1-5.

Frank, H.L.L.; Hemker, H.C.

The role of blood clotting factor V in the conversion of prothrombin and a decarboxy prothrombin into thrombin. (1978)
Biochim Biophys Acta. 1978 Feb 1;538(3):521-33.

Vermeer C, Govers-Riemslag JW, Soute BA, Lindhout MJ, Kop J, Hemker HC.

The role of gamma-carboxyglutamyl residues in the positive cooperative binding of Ca2+ to blood coagulation factor X. (1978)
Biochim Biophys Acta. 1978 Apr 26;533(2):318-26.

Lindhout MJ, Hemker HC.

The role of y-carboxyglutamil residues in the positive cooperative binding of Ca2 to blood coagulation factor x (1978)
Biochimica et Biophysica Acta, 533 (1978) 318-326.

Lindhout, M.J.; Hemker, H.C.

Thrombotest dilution curve (1978)
Thrombosis and haemostasis. 1978 Feb. No 1. Vol 39.

Hemker, H.C.

A new method for the preparation of artificial factor II reagents from normal human and bovine plasma. (1977)
Thromb Res. 1977 Mar;10(3):495-507.

Vermeer C, Soute BA, Hemker HC.

Blood coagulation factors at phospholipid surfaces (1977)
Annals of the New York Academy of Sciences. 1977 Feb. Vol 283: 104-113

Hemker, H.C.; Lindhout, M.J.; Vermeer, C.

Chemie en de kennis van ziekten (1977)
Chemisch weekblad. 1977. 593-594.

Hemker, H.C.

Determination of tissue thromboplastin activity. (1977)
Haemostasis. 1977;6(2):89-97.

Wijngaards G, Hemker HC.

Drugs affecting coagulation factor synthesis (1977)
Haemostasis : biochemistry, physiology, and pathology. 1977.

Hemker, H.C.

Ellipsometric study of protein film om chromium (1977)
Annals of the New York Academy of Sciences. 1977 Feb. Vol 283: 77-85

Cuypers, P.A.; Hermens, W.T.; Hemker, H.C.

Gezonde fijne keuken (1977)
Hart Bulletin . 1977 Okt. 139-140.

Zeguers, Jacques; Frank, H.L.L.; Hemker, H.C.

Gezonde fijne keuken (1977)
Hart Bulletin . 1977 Dec. 166-167.

Zeguers, Jacques; Hemker, H.C.

Heparin-like inhibitor of blood coagulation in normal newborn. (1977)
Nature. 1977 Jun 16;267(5612):616-7.

Muller AD, van Doorm JM, Hemker HC.

Heparin-like inhibitor, not vitamin-K deficiency, in the newborn. (1977)
Lancet. 1977 Apr 16;1(8016):852-3.

van Doorm JM, Muller AD, Hemker HC.

Kinetic aspects of the interaction of blood clotting enzymes. VII. The relation between clotting time and prothrombin concentration. (1977)
Thromb Haemost. 1977 Feb 28;37(1):81-5.

Hemker HC, Vermeer C, Govers-Riemslag J.

Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity. (1977)
Experientia. 1977 Jul 15;33(7):851-3.

Hemker HC, Frank HL.

Partial purification of the protein moiety of porcine tissue thromboplastin. (1977)
Haemostasis. 1977;6(5):269-82.

Wijngaards G, Hemker HC, van Deenen LL.

Reconstitution and lipid requirements of porcine tissue thromboplastin. (1977)
Biochim Biophys Acta. 1977 Jul 20;488(1):161-71.

Wijngaards G, van Deenen LL, Hemker HC.

The synthesis of prothrombin from its precursor protein. (1977)
Bibl Haematol. 1977;44:54-60.

Vermeer C, Hemker HC, Soute BA.

Vitamin K Deficiency in the newborn (1977)
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Doorm, van J.M.; Hemker, H.C.

Vitamin-K deficiency in the newborn. (1977)
Lancet. 1977 Oct 1;2(8040):708-9.

van Doorm JM, Hemker HC.

Demonstration of three proteins induced by vitamin K absence (PIVKAs) in the cow (1976)
Journal of Molecular Medicine, 1 (1976) 223-235.

Lindhout, M.J.; Kop-Klaassen, B.H.M.; Reekers, P.P.M.; Hemker, H.C.

Gezonde fijne keuken (1976)
Hart Bulletin . 1976 Dec. 201-202

Zeguers, Jacques; Frank, H.L.L.; Hemker, H.C.

In vitro prothrombin synthesis from a purified precursor protein :development of a bovine liver cell-free system (1976)
Biochimica et Biophysica Acta, 444 (1976) 926-930.

Vermeer, C.; Soute, B.A.M.; Govers-Riemslag, J.; Hemker, H.C.

In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system. (1976)
Biochim Biophys Acta. 1976 Oct 22;444(3):926-30.

Vermeer C, Soute BA, Govers-Riemslag J, Hemker HC.

Kinetics of the formation of the factor X activating enzyme of the blood coagulation system. (1976)
Thromb Res. 1976 Mar;8(3):303-17.

Varadi K, Hemker HC.

La coagulation : physiologie et exploration (1976)
Encyclopedie medico-chirurgicale. 1976.

Hemker, H.C.; Kahn, M.J.P.

Measuring of the extent of atherosclerotic lesions in the human by means of the assessment of the degree of activation of blood coagulation factor VII (1976)
Artery. 1975;1(4)

Muller, A.D.; Gonggrijp, R.; Hemker, H.C.

Physiologie de la coagulation (1976)
Gazette medicale de France.1976:83(15)

Hemker, H.C.; Kahn, M.J.P.

Proceedings: The relation between staphylocoagulase reacting factor and proteins induced by vitamin K absence. (1976)
Thromb Diath Haemorrh. 1975 Nov 15;34(2):593.

Bas BM, Muller AD, Hemker HC.

The estimation of activated human blood coagulation factor VII (1976)
Journal of Molecular Medicine, 1 (1976) 127-134

Hemker, H.C.; Muller, A.D.; Gonggrijp, R.

The influence of glycerol on the Ca flux in the isolated perfused rat heart. (1976)
Basic Res Cardiol. 1976 May-Jun;71(3):252-62.

Frank HL, Hemker HC.

The influence of glycerol on the Ca flux in the isolateil perfused rat heart = Der EinfluB von Glycerin auf den Ca-Flux beim isolierten, perfundierten Rattenherzen (1976)
Basic Res. Cardiol. 71,252-262 (1976')

Frank, H.L.L.; Hemker, H.C.

Theoretische Aspekte der Hyperkoagulabilitaet : Theoretische Betrachtungen ueber die Hyperkoagulabilitaet (1976)
Die Rolle der Blutplattchen bei der Thrombose ; Das Problem der Hyperkoagulabilitat. 1976 March.

Hemker, H.C.; Frank, H.L.L.; Willems, G.M.

[Autopsy in the middle ages]. (1975)
Ned Tijdschr Geneeskd. 1975 Aug 9;119(32):1246-7.

Hemker HC, Huygens RB.

Activation of a pro-enzyme by a stoichiometric reaction with another protein. The reaction between prothrombin and staphylocoagulase. (1975)
Biochim Biophys Acta. 1975 Jan 30;379(1):180-8.

Hemker HC, Bas BM, Muller AD.

Discrepancies between the one- and two-stage prothrombin estimations in purified prothrombin preparations (1975)
Prothrombin and related coagulation factors. 1975. pp. 89-92.

Hemker, H.C.; Muller, A.D.

Effect of a thrombolytic agent (urokinase) on necrosis after acute myocardial infarction. (1975)
Recent Adv Stud Cardiac Struct Metab. 1975;10:319-29.

Hermens WT, Witteveen SA, Hollaar L, Hemker HC.

Geschiedenis der geneeskunde : autopsie in de middeleeuwen (1975)
Nederlandsch tijdschrift voor geneeskunde. 1975. Vol 199. nr 32.

Hemker, H.C.; Huygens, R.B.C.

Interaction of coagulation factors (1975)
Handbook of hemophilia. 1975

Hemker, H.C.

Proceedings: Observations on monomolecular layers of fibrinogen at solid-liquid interphases. (1975)
Thromb Diath Haemorrh. 1975 Nov 15;34(2):555-6.

Cuypers PA, Hemker HC.

Purification and properties of staphylocoagulase. (1975)
Biochim Biophys Acta. 1975 Jan 30;379(1):164-71.

Bas BM, Muller AD, Hemker HC.

Quantitation of infarct size in man by means of plasma enzyme levels. (1975)
Br Heart J. 1975 Aug;37(8):795-803.

Witteveen SA, Hemker HC, Hollaar L, Hermens WT.

The influence of cadmium ions on the adsorption of prothrombin onto A1(OH)3 as a means to purify prothrombin. (1975)
Biochim Biophys Acta. 1975 Jan 30;379(1):172-9.

Devilee PP, Hemker HC, Bas BM.

The interaction between prothrombin and staphylocoagulase (1975)
The interaction between prothrombin and staphylocoagulase. 1975.

Bas, B.M.; Muller, A.D.; Graaf, de J.S.; Hemker, H.C.

A non-linear reaction scheme of blood coagulation (1974)
Present problems in haematology : leukaemia, etiology, pathogenesis, treatment, haemocoagulation and fibrinolysis, immunology of leukocytes and transplantation problems. 1974.

Hemker, H.C.; Swart, A.C.W.

Different properties of Factor VIII in von Willebrand's disease with Respectto Recovery in Cryoprecipitate. (1974)
Haemostasis. 1974;3(3):142-8.

Stibbe J, Van Der Plas PM, Hemker HC.

Effect of the polyene antibiotic filipin on the lipid-dependent intrinsic pathway of blood coagulation. (1974)
Haemostasis. 1974;3(1):1-7.

Van der Plas PM, Kraan L, Van Es G, Stibbe J, Hemker HC.

Isolation and purification of proteins induced by vitamin K absence (1974)
Physiology and biochemistry of prothrombin conversion : transactions of the twenty-first annual symposium on blood. 1973

Hemker, H.C.; Reekers, P.PM.

Puirification and properties of staphylocoagulase (1974)
Biochimica et biophysica. 1974. 379 pp 164-171

Bas, B.M.; Muller, A.D.; Hemker, H.C.

[Serine-esterases of the coagulation system]. (1973)
Pathol Biol (Paris). 1973 Nov;21:Suppl:5-10.

Hemker HC, de Graaf JS.

[Thrombocytes, thrombin, thrombosis and heart infarct]. (1973)
Ned Tijdschr Geneeskd. 1973 Jun 16;117(24):926-8.

Hemker HC.

Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist. (1973)
Biochim Biophys Acta. 1973 Aug 30;317(2):559-62.

Reekers PP, Lindhout MJ, Kop-Klaassen BH, Hemker HC.

Demonstration of three proteins induced by vitamin K absence (PIVKAs) (1973)
Transactions of the Plenary Sessions, IV International Congress on Thrombosis and Haemostasis, and Proceedings, International Committee on Thrombosis and Haemostasis. 1973

Hemker, H.C.; Lindhout, M.J.; Reekers, P.P.M.

Les serine-esterases du systeme de la coagulation (1973)
Pathologie-biologie. 1973 Nov.

Hemker, H.C.; Graaf, de J.S.

Onderzoek naar vitamine K en de bloed stollingsfactoren : wisselwerking tussen basiswetenschap en klinische praktijk is kenmerk medisch-biologisch onderzoek (1973)
Acta et agenda. 1973 Jan. 330-1

Hemker, H.C.

Plasma free of factors II, VII, IX, and X. Need for high speed centrifugation after Al(OH) 3 absorption. (1973)
Thromb Diath Haemorrh. 1973 Feb 28;29(1):211-2.

Loeliger EA, van Halem-Visser LP, Hemker HC.

The influence of glycerol on calcium in the isolated perfused rat heart. (1973)
Acta Cardiol. 1973:Suppl 17:222-4.

Frank HL, Hemker HC.

Trombocyten, trombine, trombose en het hartinfarct (1973)
Nederlandsch tijdschrift voor geneeskunde. 1973. 117 (24).

Hemker, H.C.

[The behavior of prothrombin in vitamin K deficiency]. (1972)
Ned Tijdschr Geneeskd. 1972 Oct 14;116(42):1877-80.

Hemker HC.

Artificial reagents for factor VII and factor X, a computer programme for obtaining reference tables for one-stage determinations in the extrinsic system. (1972)
Thromb Diath Haemorrh. 1972 Apr 30;27(2):205-11.

Hemker HC, Swart AC, Alink AJ.

De lotgevallen van protrombine bij vitamine-K-deficientie (1972)
Nederlandsch tijdschrift voor geneeskunde. 1972 Okt. 116 (42).

Hemker, H.C.

Differential interaction of clotting factors II, VII, IX and X with sephadex and dextran blue. (1972)
Haemostasis. 1972-1973;1(5):237-52.

Swart AC, Kop-Klaassen BH, Hemker HC.

Estimation of the rate constants in the michaelis-menten equations without restrictions as to time scale. (1972)
FEBS Lett. 1972 Aug 15;24(3):293-295.

Willems GM, Hemker HC.

Filipin as a tool for the study of blood coagulation reactions. (1972)
Thromb Diath Haemorrh. 1972 Jul 31;27(3):584-93.

van der Plas PM, Kraan L, Hemker HC.

Inhibition of blood coagulation factors by serine esterase inhibitors. (1972)
FEBS Lett. 1972 Aug 15;24(3):265-268.

De Lange JA, Hemker HC.

Lack of PIVKA effect in the abnormal factor X (factor X Friuli) coagulation disorder. (1972)
Haemostasis. 1972;1(1):23-30.

Girolami A, Muller AD, Hemker HC.

On the theory of the generation of stable inhomogeneous states in homogeneous mixtures (1972)
Analysis and simulation of biochemical systems. 1972

Hermens, W.Th.; Hemker, P.W.; Hemker, H.C.

Purification of blood coagulation factors II, VII, IX and X from bovine citrated plasma. (1972)
Haemostasis. 1972;1(1):2-22.

Reekers P, Hemker HC.

Studies on blood coagulation factor V : V. changes of molecular weight accompanying activation of factor V by thrombin and the procoagulant protein of Russell's Viper venom (1972)
MAG WEG

Kahn, M.J.P.; Hemker, H.C.

Studies on blood coagulation factor V : VI. the inactivation of factor V and prothrombinase (1972)
MAG WEG

Hemker, H.C.; Kahn, M.J.P.

Studies on blood coagulation factor V. V. Changes of molecular weight accompanying activation of factor V by thrombin and the procoagulant protein of Russell's viper venom. (1972)
Thromb Diath Haemorrh. 1972 Feb 29;27(1):25-32.

Kahn MJ, Hemker HC.

Studies on blood coagulation factor V. VI. The inactivation of factor V and prothrombinase. (1972)
Thromb Diath Haemorrh. 1972 Feb 29;27(1):33-42.

Hemker HC, Kahn MJ.

The adsorption of blood coagulation factors II, VII, IX and X from human plasma to aluminium hydroxide. (1972)
Thromb Diath Haemorrh. 1972 Jul 31;27(3):490-501.

Swart AC, Klaassen BH, Bloys-van Treslong-de, Hemker HC.

The inactivation of factor VIII in vitro. (1972)
Thromb Diath Haemorrh. 1972 Feb 29;27(1):43-58.

Stibbe J, Hemker HC, von Creveld S.

The influence of the polyene filipin on the extrinsic pathway of blood coagulation (1972)
Haemostasis: 191-203 (1972/73)

Plas, van der P.M.; Es, van G.; Kraan, L.; Hemker, H.C.

The necessary and sufficient requirement for the existence of dissipative structures in (bio)chemical systems (1972)
Stichting Mathematisch Centrum, Afdeling Toegepaste Wiskunde 1972/73

Hemker, H.C.; Willems, G.M.

Additional evidence for the existence of a precursor molecule of the prothrombin complex in oral anticoagulation. (1971)
Thromb Diath Haemorrh. 1971 Jun 30;25(2):312-5.

Veltkamp JJ, Muis H, Muller AD, Hemker HC, Loeliger EA.

De plaats van de kliniek in de biochemie (1971)
Universiteit en hogeschool.1971.18(4).

Hemker, H.C.; Kassenaar, A.A.H.

Kinetics of coagulation and immunological processes (1971)
Immunological mechanisms in blood coagulation, thrombosis and hemostasis. 1971.

Hemker, H.C.

Praktische aspecten van de antistollingsbehandeling (1971)
Hart Bulletin 2 (1971) 60

Hemker, H.C.; Veltkamp, J.J.

Quantitation of enzyme release from infarcted heart muscle. (1971)
Br Heart J. 1971 Jan;33(1):151.

Witteveen SA, Hermens WT, Hollaar L, Hemker HC.

The evaluation of the two-stage prothrombin assay. (1971)
Thromb Diath Haemorrh. 1971 Jun 30;25(3):545-54.

Hemker HC, Hemker PW, v d Torren K, Devilee PP, Hermens WT, Loeliger EA.

Theoretical consideratins on a thermodynamic model of muscle action. (1971)
Cardiovasc Res. 1971 Jul;Suppl 1:84-6.

Hemker HC, Hermens WT.

[2 types of prothrombine in vitamin K deficiency]. (1970)
Ned Tijdschr Geneeskd. 1970 Dec 26;114(52):2197-8.

Hemker HC, Muller AD, Loeliger EA.

[Protein synthesis induced by vitamin K deficiency]. (1970)
Nouv Rev Fr Hematol. 1970 Sep-Oct;10(5):645-51.

Hemker HC.

Control of long-term anticoagulant treatment. (1970)
Lancet. 1970 Apr 25;1(7652):894.

Loeliger EA, Hemker HC.

Factor IX concentrate : preparation by a simple method and clinical use (1970)
Hemophilia and new hemorrhagic states. 1970

Bruning, P.F.; Swart, A.C.W.; Veltkamp, J.J.; Hemker, H.C.; Loeliger, E.A.

Laboratory control of oral anticoagulants. Definition of therapeutic range in terms of different thromboplastin preparations. (1970)
Thromb Diath Haemorrh. 1970 Jun 30;23(3):569-84.

Loeliger EA, Meuwisse-Braun JB, Muis H, Buitendijk FJ, Veltkamp JJ, Hemker HC.

Les proteines dont la synthese est induite par l avitaminose K (1970)
Nouvelle Revue Francaise d'Hematologie.1970.10(5)pp.645-652

Hemker, H.C.

Separation of blood coagulation factors II, VII, IX and X by gel filtration in the presence of dextran blue. (1970)
Biochim Biophys Acta. 1970 Dec 29;222(3):692-5.

Swart AC, Hemker HC.

Standardization in the laboratory control of oral anticoagulants (1970)
Vascular factors and thrombosis. 1970.

Loeliger, E.A.; Hemker, H.C.

Standardization of results obtained with different thromboplastin preparations (1970)
Fibrinogen : structural, metabolic and pathophysiologic aspects. 1970.

Loeliger, E.A.; Taconis, W.K.; Veltkamp, J.J.; Hemker, H.C.

Studies on blood coagulation factor V : II preparation and properties of an artificial factor V reagent by adsorption with Ba-stearat (1970)
Coagulation. 1970.3(1).

Kahn, M.J.P.; Hemker, H.C.

Studies on blood coagulation factor V : III kinetics of the estimation of factor V (1970)
Coagulation. 1970.3(1).

Kahn, M.J.P.; Hemker, H.C.

Studies on blood coagulation factor V : IV a partially purified factor V preparation from human plasma (1970)
Coagulation. 1970.3(1).

Kahn, M.J.P.; Hemker, H.C.

The adsorption of coagulation factors onto phospholipids. Its role in the reaction mechanism of blood coagulation. (1970)
Thromb Diath Haemorrh. 1970 Oct 31;24(1):214-23.

Hemker HC, Kahn MJ, Devilee PP.

Twee typen protrombine bij vitamine K deficientie (1970)
Nederlandsch tijdschrift voor geneeskunde. 1970. 114(52).

Hemker, H.C.; Muller, A.D.; Loeliger, E.A.

Two types of prothrombin in vitamin K deficiency. (1970)
Thromb Diath Haemorrh. 1970 Jun 30;23(3):633-7.

Hemker HC, Muller AD, Loeliger EA.

[The reaction mechanism of blood coagulation]. (1969)
Ned Tijdschr Geneeskd. 1969 Feb 1;113(5):203-10.

Hemker HC, Haanen C.

Disturbances of blood clotting mechanism induced by antimetabolites of vitamin K (1969)
Vitamine A, E und K : klinische und physiologisch-chemische Probleme. 1969.

Hemker, H.C.; Meer, van der J.; Hodge, R.; Loeliger, E.A.

H. The kinetics of enzyme cascade systems. General kinetics of enzyme cascades. (1969)
Proc R Soc Lond B Biol Sci. 1969 Jul 1;173(32):411-20.

Hemker HC, Hemker PW.

Het reactiemechanisme van de bloedstolling (1969)
Nederlandsch tijdschrift voor geneeskunde. 1969.113(5)

Hemker, H.C.; Haanen, C.

Studies on blood coagulation factor V. I. The interaction of salts of fatty acids and coagulation factors. (1969)
Thromb Diath Haemorrh. 1969 Dec 31;22(3):417-30.

Kahn MJ, Hemker HC.

The kinetics of enzyme cascade systems : general kinetics of enzyme cascades (1969)
Proceedings of the Royal Society of London, Series B, Biological sciences. 1969. 173, 411-420.

Hemker, H.C.; Hemker, P.W.

[Arvin, a new anticoagulant]. (1968)
Ned Tijdschr Geneeskd. 1968 Oct 26;112(43):1958-60.

Hemker HC, Loeliger EA.

[Prothrombin time and Thrombotest in anticoagulant treatment]. (1968)
Ned Tijdschr Geneeskd. 1968 Nov 30;112(48):2195-8.

Loeliger EA, Hemker HC.

[Treatment of hemophilia B with PPSB]. (1968)
Blut. 1968 Feb;16(5):289-97.

Loeliger EA, Mattern MJ, Hensen A, Hemker HC.

Behandlung der Haemophilie B mit PPSB (1968)
Blut. 1968. Band XVI.

Loeliger, E.A.; Mattern, M.J.; Hensen, A.; Hemker, H.C.

Considerations on an international standard for the one-stage prothrombin time in the control of anticoagulant therapy. (1968)
Thromb Diath Haemorrh Suppl. 1968;35:101-5.

Loeliger EA, Hemker HC.

Kinetic aspects of the interaction of blood clotting enzymes. 3. Demonstration of an inhibitor of prothrombin conversion in vitamin K deficiency. (1968)
Thromb Diath Haemorrh. 1968 Jul 31;19(3):346-63.

Hemker HC, Veltkamp JJ, Loeliger EA.

Kinetic aspects of the interaction of blood clotting enzymes. IV. Kinetics of competitive inhibition in clotting tests. (1968)
Thromb Diath Haemorrh. 1968 Jul 31;19(3):364-7.

Hemker HC, Hemker PW.

Kinetic aspects of the interaction of blood clotting enzymes. V. The reaction mechanism of the extrinsic clotting system as revealed by the kinetics of one-stage estimations of coagulation enzymes. (1968)
Thromb Diath Haemorrh. 1968 Jul 31;19(3):368-82.

Hemker HC, Muller AD.

Kinetic aspects of the interaction of blood-clotting enzymes. VI. Localization of the site of blood-coagulation inhibition by the protein induced by vitamin K absence (PIVKA). (1968)
Thromb Diath Haemorrh. 1968 Nov 15;20(1):78-87.

Hemker HC, Muller AD.

Pharmacological aspects of vitamin K1. A clinical and experimental study in man. (1968)
Thromb Diath Haemorrh Suppl. 1968;29:1-96.

Van der Meer J, Hemker HC, Loeliger EA.

Principles of the mode of action of coumarin congeners (1968)
Drugs in relation to blood coagulation, haemostasis and thrombosis. 1968. Vol 6.

Loeliger, E.A.; Hemker, H.C.

A double-blind trial of long-term anticoagulant treatment after myocardial infarction. (1967)
Acta Med Scand. 1967 Nov;182(5):549-66.

Loeliger EA, Hensen A, Kroes F, van Dijk LM, Fekkes N, de Jonge H, Hemker HC.

Contact activation in the extrinsic blood clotting system. (1967)
Thromb Diath Haemorrh. 1967 Dec 31;18(3-4):525-31.

Altman R, Hemker HC.

Formation of prothrombin converting activity. (1967)
Nature. 1967 Jul 15;215(5098):248-51.

Hemker HC, Esnouf MP, Hemker PW, Swart AC, Macfarlane RG.

Kinetic aspects of the interaction of blood-clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin-time estimations. (1967)
Thromb Diath Haemorrh. 1967 May 31;17(3-4):349-57.

Hemker HC, Siepel T, Altman R, Loeliger EA.

Reaction sequence of blood coagulation. (1967)
Nature. 1967 Sep 9;215(5106):1201-2.

Hemker HC, Kahn MJ.

The pathways of blood coagulationl. (1967)
Folia Med Neerl. 1967;10(4):102-11.

Hemker HC.

Treatment of haemophilia A with purified factor 8 obtained from human plasma by cryoprecipitation. (1967)
Folia Med Neerl. 1967;10(2):49-60.

Meyer K, Eernisse JG, Veltkamp JJ, Hemker HC, Loeliger EA.

Treatment of haemophilia B with purified Factor IX (PPSB). (1967)
Folia Med Neerl. 1967;10(4):112-25.

Loeliger EA, Hensen A, Mattern MJ, Veltkamp JJ, Bruning PF, Hemker HC.

A double blind study of phenprocoumon prophylaxis after myocardial infarction. (1966)
Thromb Diath Haemorrh Suppl. 1966;21:333-6.

Hensen A, Kroes F, Van Dyck LM, Fekkes N, Hemker HC, Loeliger EA.

Quantitation of circulating fibrinogen breakdown products in intravascular clotting. (1966)
Thromb Diath Haemorrh Suppl. 1966;20:227-34.

Hemker HC, Fekkes N, Hensen A, Schrijver H, Loeliger EA.

[DETERMINATION OF DIFFERENTIAL LIVER FUNCTION USING OWREN'S THROMBOTEST]. (1965)
Ned Tijdschr Geneeskd. 1965 Apr 3;109:646-52.

HEMKER HC, VAN DER MEER J, LOELIGER EA.

Detection of heterozygotes for factor 8, 9, and 12 deficiency. (1965)
Thromb Diath Haemorrh Suppl. 1965;17:181-9.

Veltkamp JJ, Hemker HC, Loeliger EA.

Differentiele leverfunctiebepaling met behulp van de trombotest van Owren (1965)
Nederlands Tijdschrift voor Geneeskunde. 1965;100(14).

Hemker, H.C.; Meer, van der J.; Loeliger, E.A.

KINETIC ASPECTS OF THE INTERACTION OF BLOOD CLOTTING ENZYMES. I. DERIVATION OF BASIC FORMULAS. (1965)
Thromb Diath Haemorrh. 1965 Mar 15;13:155-75.

HEMKER HC, HEMKER PW, LOELIGER EA.

Kinetic basis of prothrombin estimation particularly with reference to the rectilinearity of the log-log reference curve. (1965)
Thromb Diath Haemorrh Suppl. 1965;17:247-52.

Hemker HC, van der Meer J, Loeliger EA.

Rate of synthesis of coagulation factors II, VII, IX, and X during substitution therapy with P. P. S. B. (1965)
Bibl Haematol. 1965;23:1346-7.

Loeliger EA, Hensen A, Mattern MJ, Hemker HC.

THE BIOLOGICAL HALF-TIME OF HAGEMAN FACTOR. (1965)
Thromb Diath Haemorrh. 1965 Mar 15;13:1-7.

VELTKAMP JJ, LOELIGER EA, HEMKER HC.

[QUANTITATIVE BLOOD COAGULATION TESTS]. (1964)
Maandschr Kindergeneeskd. 1964 Aug;32:503-11.

HEMKER HC.

BEHAVIOUR OF FACTORS II, VII, IX AND X IN BLEEDING COMPLICATIONS DURING LONG-TERM TREATMENT WITH COUMARIN. (1964)
Thromb Diath Haemorrh. 1964 Jan 1;10:278-81.

LOELIGER EA, HENSEN A, MATTERN MJ, HEMKER HC.

Inhibition of adenosine triphosphatase and respiration of rat-liver mitochondria by dinitrophenols (1964)
Biochimica et biophysica acta. 1964.Vol.81.

Hemker, H.C.

Kwantitering in de bloedstolling (1964)
Maandschrift voor kindergeneeskunde.1964.

Hemker, H.C.

THE BIOLOGICAL DISAPPEARANCE RATE OF PROTHROMBIN, FACTORS VII, IX AND X FROM PLASMA IN HYPOTHYROIDISM, HYPERTHYROIDISM, AND DURING FEVER. (1964)
Thromb Diath Haemorrh. 1964 Jan 1;10:267-77.

LOELIGER EA, VAN DER ESCH B, MATTERN MJ, HEMKER HC.

The mode of action of dinitrophenols on the different phosphorylating steps (1964)
Biochimica et biophysica acta. 1964.Vol.81

Hemker, H.C.

NATURE OF PROTHROMBIN BIOSYNTHESIS: PREPROTHROMBINAEMIA IN VITAMIN K-DEFICIENCY. (1963)
Nature. 1963 Nov 9;200:589-90.

HEMKER HC, VELTKAMP JJ, HENSEN A, LOELIGER EA.

The contribution of the various phosphorylating steps in the respiratory chain to the dinitrophenol-induced ATPase of rat-liver mitochondria. (1963)
Biochim Biophys Acta. 1963 Jun 11;73:311-23.

HEMKER HC.

A new application of the Clark oxygen electrode. (1962)
Biochim Biophys Acta. 1962 Jul 16;60:646-7.

HEMKER HC.

Het mechanisme van de werking van ontkoppelende fenolen op de ademhalingsketen-fosforylering (1962)
Thesis.1962.

HEMKER HC.

Lipid solubility as a factor influencing the activity of uncoupling phenols. (1962)
Biochim Biophys Acta. 1962 Sep 10;63:46-54.

HEMKER HC.

Dinitrophenol-induced ATPase of rat-liver mitochondria. (1961)
Biochim Biophys Acta. 1961 Mar 18;48:221-3.

HEMKER HC. HULSMANN WC.

Inhibition of enzymes by Atebrin. (1960)
Biochim Biophys Acta. 1960 Oct 21;44:175-7.

HEMKER HC, HULSMANN WC.

Contact

Prof. H.C. Hemker

Office:
Oxfordlaan 70
6229 EV Maastricht
Tel: +31 43 38858952
Fax: +31 43 3670916